International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 6 9 2016 09 18 Evaluation of New 2-N-tert-butyl-5-aryl-1, 3, 4-Oxadiazol-2-Amines for Antimicrobial Activity 55 57 EN S.K. Pagariya 1 Department of Chemistry, Vidyabharati Mahavidyalaya, Amravati-444602, Maharashtra, India R.M. Pathade 2 Department of Chemistry, Vidyabharati Mahavidyalaya, Amravati-444602, Maharashtra, India P.S. Bodkhe 3 Department of Chemistry, Vidyabharati Mahavidyalaya, Amravati-444602, Maharashtra, India Vandna Pathak 1 M.G.C.G.V., Satna, MP, India Ravindra Singh 2 M.G.C.G.V., Satna, MP, India Pankaj Gautam 3 M.G.C.G.V., Satna, MP, India L.G. Ndiaye 1 Département de Physique, BP.523 Ziguinchor, Sénégal, Université Assane Seck de Ziguinchor, Ziguinchor, 523, Senegal A. Diedhiou 2 Département de Physique, BP.523 Ziguinchor, Sénégal, Université Assane Seck de Ziguinchor, Ziguinchor, 523, Senegal and Centre de recherche de Royallieu, EA 4297-TIMR, Université de Technologie de Compiègne, Compiègne, BP20529 – 60205, France A. Bensakhria 3 Centre de recherche de Royallieu, EA 4297-TIMR, Université de Technologie de Compiègne, Compiègne, BP20529 – 60205, France O. Sock 4 Centre de recherche de Royallieu, EA 4297-TIMR, Université de Technologie de Compiègne, Compiègne, BP20529 – 60205, France R. Atiko 1 Department of Chemistry, Faculty of Science, Gombe State University, Gombe, Nigeria P.A. Onocha 2 Department of Chemistry, Faculty of Science, University of Ibadan, Ibadan, Nigeria S.O. Oyedemi 3 Phytomedicine Research Centre, Botany Department, University of Fort Hare, Alice, South Africa Dutta Koushik 1 Department of Environmental Science, Sambhu Nath College, Labpur, Birbhum, W.B., India Apurba Ratan Ghosh 2 epartment of Environmental Science, The University of Burdwan, Burdwan, W.B., India G. Amala Jothi Grace 1 Manonmaniam Sundranar University, Tirunelveli, India and Department of Chemistry, Chandy College of Engineering, Thoothukudi, India A. Gomathi 2 Department of Chemistry, Sri K.G.S Arts and Science College, Srivaikuntam, India C. Vedhi 3 Department of Chemistry, V.O.Chidambaram College, Thoothukudi, India P.D. Shelke 1 P.G. Department of chemistry, New Arts, Commerce and Science College Ahmednagar, Affiliated to S. P. Pune University, India and Department of Chemistry, Dr. Babasaheb Ambedakar Marathwada University, Aurangabad, India A.S. Rajbhoj 2 Department of Chemistry, Dr. Babasaheb Ambedakar Marathwada University, Aurangabad, India M.S. Nimase 3 P.G. Department of chemistry, New Arts, Commerce and Science College Ahmednagar, Affiliated to S. P. Pune University, India S.J. Takate 4 P.G. Department of chemistry, New Arts, Commerce and Science College Ahmednagar, Affiliated to S. P. Pune University, India .H. Zaware B 5 P.G. Department of chemistry, New Arts, Commerce and Science College Ahmednagar, Affiliated to S. P. Pune University, India S.S Jadhav 6 P.G. Department of chemistry, New Arts, Commerce and Science College Ahmednagar, Affiliated to S. P. Pune University, India M.U. Ibezim-Ezeani 1 Department of Pure and Industrial Chemistry, University of Port Harcourt, P.M.B. 5323, Choba, Port Harcourt, Nigeria A.F. Okon 2 Department of Pure and Industrial Chemistry, University of Port Harcourt, P.M.B. 5323, Choba, Port Harcourt, Nigeria N.A. Rashidi 1 Department of Chemistry, Mungsaji Maharaj Mahavidyalaya, Darwha, Dist: Yavatmal, MS, India B.N. Berad 2 Department of Chemistry, RTM Nagpur University, Nagpur, MS, India > Short Communication 2016 4 22 2016 09 18 A series of five membered heterocyclic oxadiazole derivatives synthesized by intramolecular cyclisation of N-tert-butyl-2-aroyl hydrazine carbothioamides (IIa-g) with iodine-pot.iodide in basic medium were tested for their biological activities against selected microorganisms. The newly synthesized compounds were investigated for their antimicrobial activities by Agar diffusion method. For antibacterial study, the bacterial strain used included both gram-positive strains like Ecoli and gram negative strain S.aureus. Antifungal activity was performed against the fungus A. niger. Among the synthesized compounds (IIIa-g), few compounds showed weak antimicrobial activities in comparison with standard drugs. Copyright@ International Science Community Association