International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 2 7 2012 July 18 Antinociceptive and Antiinflammatory Effects of the Methanolic extract of Oscillatoria annae 53 61 EN Kumar Harish 1 Material Science Laboratory, Department of Chemistry, Ch. Devi Lal University, Sirsa, Haryana, INDIA Sunita 2 Department of Chemistry, Singhania University, Rajasthan, INDIA Diwya 1 Acharya institute of Technology, Soldevanahalli, Hesarghatta Road, Bangalore-560090, Karnataka, INDIA Iyengar Pushpa 2 Department of Chemistry, Jyoti Nivas College, Koramangala Industrial Layout, Bangalore - 560095, Karnataka, INDIA Ramachandrappa R. 3 Bobade S.N. 1 Indian Biodiesel Corporation, Baramati, above Sh. Malojiraje Co-op. Bank, Tal- Baramati, Dist- Pune, MS, INDIA Shardabai Pawar Mahila College, Khyade V.B. 2 Shardanagar, Tel. Baramati, Dist – Pune, MS, INDIA Mihayo I.Z. 1 Dept. of Physical Sci, Faculty of Science, Sokoine University of Agriculture, Chuo Kikuu, Morogoro, TANZANIA Mkoma S.L. 2 Kannan C. 1 Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli-627012, Tamilnadu, INDIA Devi M.R. 2 Muthuraja K. 3 Esaivani K. 4 SudalaiVadivoo V. 5 Mishra Subhra 1 Department of Chemistry, Alipurduar College, North Bengal University, Pin-736122, West Bengal, INDIA Sunakar Panda 1 P.G.Dept of Chemistry,Berhampur University, Ganjam-760007,Odisha, INDIA Chandra PanigrahiJagadish 2 Pulp and Paper Research Institute, Jaykaypur, Rayagada-765017, Odisha, INDIA Tripathy UpendraPrasad 3 Ramyadevi D. 1 Department of Chemical Engineering, National Institute of Technology, Tiruchirappalli- 620 015, INDIA Subathira A. 2 Saravanan S. 3 Rajavel R. 1 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Erode-638 052, Tamil Nadu, INDIA Mallika P. 2 Department of Microbiology, Bharathidasan University, Trichy, Tamil Nadu, INDIA Rajesh V. 3 Department of Pharmacology, J.K.K. Nataraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, INDIA PavanKumar K. 4 MoorthyS. Krishna 5 Sivakumar T. 6 > Research Paper 2012 4 12 2012 July 18 The present study was designed to investigate antiinflammatory and antinociceptive activities of Oscillatoria annae. The antiinflammatory activity were studied in both acute and chronic inflammation models, where as by using four different animal models were employed to evaluate the antinociceptive activity of the extract in the acute model, carrageenan, dextran, histamine and serotonin were used to induce the inflammation in rat hind paw and cotton pellet enhanced granuloma method was used for chronic inflammation model. Acetic acid-induced writhing method, hot plate method, tail flick response and tail immersion method were used to evaluate the antinociceptive effect of the extract. The methanolic extract of Oscillatoria annae exhibited significant dose-dependent activity on the tested experimental animal models, and also on the extract significantly reduced in the acetic acid-induced abdominal contractions and the increased reaction time of mice in hot plate method, tail flick response and tail immersion method. This study has shown that the methanolic extract from the Oscillatoria annae does possess significant antiinflammatory and antinociceptive activity in animal models at the doses tested and the results were comparable to those observed for the standard drugs indomethacin, acetyl salicylic acid and morphine. Copyright@ International Science Community Association