International Science Community Association Research Journal of Chemical Sciences 2231 - 606X 2 7 2012 July 18 Synthesis and Antimicrobial Activity of Azetidin-2-one Containing Pyrazoline Derivatives 62 68 EN Kumar Harish 1 Material Science Laboratory, Department of Chemistry, Ch. Devi Lal University, Sirsa, Haryana, INDIA Sunita 2 Department of Chemistry, Singhania University, Rajasthan, INDIA Diwya 1 Acharya institute of Technology, Soldevanahalli, Hesarghatta Road, Bangalore-560090, Karnataka, INDIA Iyengar Pushpa 2 Department of Chemistry, Jyoti Nivas College, Koramangala Industrial Layout, Bangalore - 560095, Karnataka, INDIA Ramachandrappa R. 3 Bobade S.N. 1 Indian Biodiesel Corporation, Baramati, above Sh. Malojiraje Co-op. Bank, Tal- Baramati, Dist- Pune, MS, INDIA Shardabai Pawar Mahila College, Khyade V.B. 2 Shardanagar, Tel. Baramati, Dist – Pune, MS, INDIA Mihayo I.Z. 1 Dept. of Physical Sci, Faculty of Science, Sokoine University of Agriculture, Chuo Kikuu, Morogoro, TANZANIA Mkoma S.L. 2 Kannan C. 1 Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli-627012, Tamilnadu, INDIA Devi M.R. 2 Muthuraja K. 3 Esaivani K. 4 SudalaiVadivoo V. 5 Mishra Subhra 1 Department of Chemistry, Alipurduar College, North Bengal University, Pin-736122, West Bengal, INDIA Sunakar Panda 1 P.G.Dept of Chemistry,Berhampur University, Ganjam-760007,Odisha, INDIA Chandra PanigrahiJagadish 2 Pulp and Paper Research Institute, Jaykaypur, Rayagada-765017, Odisha, INDIA Tripathy UpendraPrasad 3 Ramyadevi D. 1 Department of Chemical Engineering, National Institute of Technology, Tiruchirappalli- 620 015, INDIA Subathira A. 2 Saravanan S. 3 Rajavel R. 1 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Erode-638 052, Tamil Nadu, INDIA Mallika P. 2 Department of Microbiology, Bharathidasan University, Trichy, Tamil Nadu, INDIA Rajesh V. 3 Department of Pharmacology, J.K.K. Nataraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, INDIA PavanKumar K. 4 MoorthyS. Krishna 5 Sivakumar T. 6 Shah ShaileshH. 1 Dept. of Chem., Patel JBR Arts, Patel AMR Commerce and Patel JDKD Science College, Borsad, GJ, & JJT-University, RJ, INDIA PatelPankaj S. 2 Department of Chemistry, Sheth LH Science College, Mansa, Gujarat, INDIA > Research Paper 2012 5 11 2012 July 18 Pyrazolines are well-known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. A new series of 3-chloro-1-{4-[5-(Substitutedphenyl)-4,5-dihydro-pyrazol-3-yl]phenyl}-4-(4-hydroxyphenyl) azetidin-2-one are synthesized by reacting 3-chloro-1-{4-[3-(Substituted phenyl)prop-2-enoyl]phenyl}-4-(4-hydroxyphenyl)azetidin-2-one with 99% hydrazine hydrate. All these compounds were characterized by means of their IR, H NMR, Spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method. Copyright@ International Science Community Association