International Science Community Association Research Journal of Chemical Sciences 2231-606X 12 2 2022 06 18 Synthesis, characterization, molecular docking and antibacterial evaluation of 3-aryl-1- phenyl-1H-pyrazole- 4-carbaldehyde-acylhydrazones 21 24 EN Narmatha M 1 Vivekanand College of Engineering for Women, Namakkal, Elaiyampalayam, Tamil Nadu, India I.V. Haruna 1 Department of Geology, Modibbo Adama University of Technology, Yola P.M.B. 2076, Yola – Nigeria H.A. Ahmed 2 Department of Geology, Modibbo Adama University of Technology, Yola P.M.B. 2076, Yola – Nigeria B.M. Suleiman 3 Department of Geology, Modibbo Adama University of Technology, Yola P.M.B. 2076, Yola – Nigeria Rao Sangeetha 1 KLE’s S. Nijalingappa College, Rajajinagar, Bengaluru-10, India > Research Paper 2021 3 12 2022 06 18 In view of fostering research on efficacious antimicrobials, a series of new 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde acylhydrazones were synthesized in three steps commencing with the reaction of substituted acetophenones with phenyl hydrazine to yield respective Schiff bases. The respective formyl pyrazoles were synthesized from the Schiff bases by subjecting them to Vilsmeier-Haack formylation. The recrystallized formyl pyrazoles were then treated with substituted benzoic acid hydrazides in ethanol medium with acetic acid as the catalyst to obtain 3-Aryl-1-phenyl-1H-pyrazole-4-carbaldehyde acylhydrazones (4a-4e). The pyrazole derivatives were assessed for their effective inhibitory properties against bacterial DNA Gyrase B enzymes by molecular docking studies which were then evaluated for their in vitro antibacterial activities. Copyright@ International Science Community Association