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Antibacterial screening of novel Mannich bases of 5H-dibenzo [b,f]azepine-5-corboxamide

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Author Affiliations

  • 1School of Chemical Sciences, Devi Ahilya Vishvavidyalaya, Khandwa Road, Indore-452001, Madhya Pradesh, India
  • 2School of Chemical Sciences, Devi Ahilya Vishvavidyalaya, Khandwa Road, Indore-452001, Madhya Pradesh, India

Res. J. Recent Sci., Volume 6, Issue (10), Pages 10-13, October,2 (2017)

Abstract

Current work involves antibacterial screening of Mannich bases of 5H-dibenzo[b,f]azepine-5-carboxamide. A series of Mannich bases of 5H-dibenzo[b,f]azepine-5-carboxamide (4a-4j) were synthesized via Mannich reaction of 5H-dibenzo[b,f]azepine-5-carboxamide with primary/secondary amines and formaldehyde. After characterization of Mannich bases by spectroscopic techniques i.e. UV, IR, 1H NMR and 13C NMR, compounds of series (4a-4j) were screened against pathogen K. pneumoniae. Sulfonamides that used as primary amine during synthesis of mannich bases were also screened against pathogen K. pneumonia and results obtained were compared with synthesized mannich bases. Antibacterial activities of synthesized Mannich bases and sulfonamides have been determined in term of ‘zone of inhibition’. Result obtained shows some of newly synthesized Mannich bases have potent antibacterial activity against pathogen K. pneumoniae.

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