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Evaluations of some Serum Biochemical Parameters and Antibiotics Susceptibility Pattern in Enterococcus faecalis Infected Patients

Author Affiliations

  • 1Department of Medical Laboratory Science (Chemical Pathology Option), Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, P.M.B. 071, Bayelsa State, Nigeria
  • 2Department of Medical Laboratory Science (Chemical Pathology Option), Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, P.M.B. 071, Bayelsa State, Nigeria
  • 3Department of Medical Laboratory Science (Medical Microbiology/Parasitology Option), Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, P.M.B. 071, Bayelsa State, Nigeria

Res. J. Recent Sci., Volume 5, Issue (4), Pages 1-5, April,2 (2016)

Abstract

The evaluations of some serum biochemical parameters and antibiotics susceptibility pattern in Enterococcus faecalis infected patients were studied. Early morning midstream urine and blood specimens were collected from thirty Enterococcus faecalis infected patients aged 18-35 years and from another thirty subjects with no evidence of infection (control) aged 18-35 years. The following serum biochemical parameters: creatinine, total protein, albumin, globulin, C-reactive protein, sodium, potassium, chloride and bicarbonate were quantitatively measured while antibiotics susceptibility test was performed on the pure isolate of Enterococcus faecalis obtained from the cultured urine specimen using the disc diffusion method. The results of this study showed that there was significant difference of serum C-reactive protein in the Enterococcus faecalis infected patients as compared with that of the control subjects while there were no significant differences in the other serum biochemical parameters of the Enterococcus faecalis infected patients as compared with that of the control subjects. However, the antibiotics susceptibility results showed that only two antibiotics: pefloxacin and ciprofloxacin had considerable susceptibility of 56.67% and 66.69% respectively while others showed very poor susceptibility as follow: ofloxacin 46.67%, gentamycin 36.67%, ampiclox 23.33%, erythromycin 33.33%, norfloxacin 20%, chloramphenicol 16.67%, clindamycin 20% and streptomycin 26.67%. In conclusion, this study has revealed that serum C-reactive protein concentration is significantly elevated in Enterococcus faecalis infected patients and ciprofloxacin among the several antibiotics used for this research work has proved to be the most susceptible antibiotic for the empirical treatment of this infection in the studied community followed by pefloxacin.

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