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Study of Antioxidant and Antimicrobial Activity of Medicinal Plants Utilized in Cancer Treatment

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Author Affiliations

  • 1Department of Biotechnology, Veer Narmad South Gujarat University, Udhana Magdhalla Road, Surat INDIA

Res. J. Recent Sci., Volume 4, Issue (IVC-2015), Pages 15-21, (2015)

Abstract

In our modern society word Cancer is becoming very common as various types of Cancer are effecting large population worldwide. Need of hour is to find the effective treatment of these cancers through research on different plants which can be a good source of components effective in its treatment. The state of uncontrolled growth of cell is Cancer. Various species of plants have been used in the preparation of drugs utilized for the treatment of malignant diseases. Phytochemicals are the chemical substances producing definite physiological action on human body. They found to have antioxidants which are also called free radical scavangers protecting the cells from different types of Cancer. In our studies we have selected six medicinal plants as Aegle marmelos (Leaves), Vernonia anthelmintica (Seeds), Zingiber officinalis (Rhizome), Tinospora cordifolia (Stem) and Phyllanthus acidus (Leaves) of Gujarat region which are reported to have role in cancer therapy due to the presence of different phytochemicals like phenolics, tannins, flavonoids etc. Aqueous and Organic extracts of different parts of these plants were prepared. Antioxidant activity was measured through DPPH and ABTS radical scavenging assay and antimicrobial activity through Agar Well Diffusion method. Antimicrobial activity was tested on some disease causing microorganisms like Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Salmonella typhii, Aspergillus niger and Penicillium notatum. DPPH assay had revealed that organic extract of Vernonia anthelmintica and aqueous extract of Zingiber officinalis was found to have IC50 values 124 and 132 µg/ml respectively. Antimicrobial activity of different extracts had shown that maximum diameter of Zone of Inhibition (24mm at 1g/ml) was obtained with organic extract of Tinospora cordifolia. No antifungal activity was observed with any of the plant species extracts. It can be concluded from the studies that the extracts of all test six plants possessed significant antioxidant and antibacterial activities which conforms their role in cancer studies.

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