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HPLC phytochemical analysis and antiproliferative activity of n-butanol fraction of Solanum aethiopicum L. (Solanaceae) from Côte d’Ivoire

Author Affiliations

  • 1Laboratoire de Chimie Bio Organique et de Substances Naturelles (LCBOSN), UFR-SFA, Universit Nangui Abrogoua, 02 BP 0801 Abidjan 02,COTE DIVOIRE
  • 2 Biomedical Laboratory Science and Technology, Department of Biomedical Sciences, Health and Society, Malm University, SE-205 06 Malm,SWEDEN

Res. J. Recent Sci., Volume 4, Issue (12), Pages 81-87, December,2 (2015)

Abstract

Solanum aethiopicum L. (Solanaceae) commonly called Aubergine, is a popular plant and one of the most eaten as a leaf and vegetable. Due to the lack of phytochemical and biological information on the species of Cte d'Ivoire, the goal of our previous investigations was mainly a qualitative analysis by TLC and anti-hypertensive activity of organic extracts from the flower stalk. This research has highlighted the richness of the plant in different secondary metabolites and an efficient in vivo hypotensive activity. The aim of the present work was to certify by HPLC analyzes, the phytochemical composition of n- butanol fraction (F4) of S. aethiopicum flower stalk obtained from the methanol extract and study its anticancer activity on Jurkat cell lines. The results have confirmed our previous findings in relation to the diversity of bioactive phytocompounds contained in S. aethiopicum flower stalk; on one hand, Quercetin identified in F4 at a retention time of 2.65 min and on the other hand, F4 induces in vitro antiproliferative and apoptotic activities on Jurkat cells with IC50= 11.77 2.4 mg/ml.

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