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Blood Lipid profile in Sudanese hypothyroid patients

Author Affiliations

  • 1 Department of Biochemistry, Faculty of Medicine and Health Sciences, University of Dongola, SUDAN

Res. J. Recent Sci., Volume 4, Issue (12), Pages 68-70, December,2 (2015)

Abstract

The effect of hypothyroidism on the blood lipids profile in Sudanese hypothyroidism patients were studied in (80) individuals divided into two groups. Forty hypothyroid patients and (40) euthyroid. They were chosen from the patients visiting the National Tumour Centre (NTC) in Khartoum State. The study carried out from (October 2000 up to April 2001). The objective of this study was to estimate the levels of thyroid hormones and lipid profile parameters of Sudanese hypothyroid patients compared them to control group, and also to study the effect of hypothyroid condition in lipid profile answer specific question about difference in sex factor between males and females. Blood sample were taken, thyroid hormones measurement used immunradometric assay (IRMA) and radioimmun assay (RIA), which used specific reagents obtained from department of isotope (Beijing, china), lipids profile test were measured by commercial kits of enzyetic-spectrophotometric, from Biosystem, S.A brova, Barcelona (Spain). The means levels results of thyroid hormones T4, T3 showed significant (P < 0.001) decreased in hypothyroid groups compared to control groups of both sex. TSH showed significant (P < 0.001) increased in hypothyroid groups compared to control groups of both sex Table-1. The means level of total lipids and triglycerol showed significant (P < 0.001) increased in hypothyroid of both sex compared to control group, but hypothyroid female showed slight increased without significant when compared to males hypothyroid Table-2. The means levels of cholesterol and phospholipids showed significantly increased (P < 0.001) in hypothyroid groups of both sex compared to control group of both sex Table-3. In contrast to total lipids and traiacylglycerol of hypothyroid males the means level of cholesterol and phospholipids showed increased when compared to hypothyroid females Table-3. This study concluded that the levels of thyroid hormones in hypothyroid group reported lower values of T4 and higher values of TSH compared to euthyroid subjects, but T3 exhibited no clear difference between hypothyroid groups and euthyroid groups. The four lipids parameters reported higher values in hypothyroid subjects compared to the euthyoid. The plasma lipids profile is highly affected in hypothyroid female reported significantly (P < 0.001) higher triacylglycerol levels compared to males group.

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