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Small Bite - Big Threats: Assessment of Pernicious Repercussion of Antimalarial Drugs

Author Affiliations

  • 1 Amity University, Noida, Uttar Pradesh, INDIA

Res. J. Recent Sci., Volume 3, Issue (IVC-2014), Pages 1-4,(2014)

Abstract

Malaria is one of the most grievous public health problems worldwide. Most of the regions falling in tropical and subtropical areas receiving high rainfall are facing this threat and it is major cause of mortality in these regions. This deadly disease has promulgated into most of the Asian nations which are on the threshold of development. It has been observed that Antimalarial drugs that are prescribed for treatment of malaria do produce symptoms of toxicity because of over dosage or drug reactions consequent upon administration of Antimalarials. Various Antimalarial drugs such as Mefloquine, Halofantrine, Artether, Artemether etc. are known to have caused clinical manifestations such as Neuropsychiatric toxicity, Neurotoxicity, Cardio respiratory collapse and death. The present study reviews the articles stating the clinical findings in the cases of antimalarial drugs toxicity.

References

  1. http://www.who.int/malaria/media/world_malaria_report_ (2013)
  2. Peto T.E.A., Toxicity of Antimalarial drugs, J of Royal Soc. of Med., 1(82), (1989)
  3. Alkadi H.O., Antimalarial Drug toxicity : A Review, Chemo J., (2007)
  4. Khanna N., Antimicrobial Agents: Antiprotozoal Drugs, Pharmacology,82, (2007)
  5. Harrison A.C., Bioactivation and detoxification of amodiaquine, Xeno J., 25(2), 199-217 (1995)
  6. Touze J.E., Heno P., Fourcade I., Deharo J.C., Thomas G., Bohan S., Paule P., Riviere P. and Kouassi E., The Effects of Antimalarial drugs on ventricular repolarization, J. Trop. Med. Hyg., 67(1), 54–60(2002)
  7. Kinoshita A., Yamada H., Kotaki H. and Kimura M., Effects of Anti-Malarial drugs on the Electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system, Malar J,. 9, 318 (2010)
  8. Bouchaud O., Imbert P., Touze J.E., Dodoo A.N. and Danis M., Legros F., Fatal Cardiotoxicity related to Halofantrine: A review based on a worldwide safety data base, Malar J. 8, 289 (2009)
  9. White N. J., Cardiotoxicity of antimalarial drugs, Lanc Infect Dis., 7(8), 549-58 (2007)
  10. Traebert M. and Dumotier B., Antimalarial drugs: QT prolongation and cardiac arrhythmias, Expert Opin Drug Saf. , 4(3), 421-31 (2005)
  11. Maude R.J., Plewes K, Faiz M.A, Hanson J, Charunwatthana P, Lee S. J. and Tärning J., Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?, Am J Trop Med Hyg., 80(1), 126-32 (2009)
  12. Thapa R., Patra V. and Kundu R., Plasmodium vivax cerebral malaria, Indian Pediatr, 44(6), 4334 (2007)
  13. Carter J.A., Mung'ala-Odera V., Neville B.G., Murira G., Mturi N. and Musumba C., Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children, J. Neurol Neurosurg Psychiatry, 76(4), 47681 (2005)
  14. Winstanley P. and Ward S., Malaria chemotherapy, Adv Parasitol, 61, 47-76 (2006)
  15. Genovese R.F., Nguyen H.A. and Mog S.R., Effects of arteether on an auditory radial-arm maze task in rats, Physiol Behav., 73(1-2), 87-91(2001)
  16. Brewer T. G., Grate S. J., Peggins J.O., Weina P.J., Petras J.M., Levine B.S., Heiffer M.H. and Schuster B.G., Fatal neurotoxicity of arteether and artemether, Am J Trop Med Hyg. 51(3), 251-9 (1994)
  17. Nosten F. and Price R.N., New antimaiarials: a risk-benefit analysis, Drug Saf, 12(4), 264-73 (1995)
  18. Clark R.L., Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester, J. Reprod Toxicol., 28(3), 285-96 (2009)
  19. Bhatt T.K., Computational Studies on Calpain from Plasmodium Falciparum, Res. J. of Rec. Sc., 1(9), 79-82 (2012)
  20. Clark R.L., White T.E., Clode S.A., Gaunt I., Winstanley P. and Ward S.A., Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit, Res. B. Dev. Reprod Toxicol., 71(6), 380-94 (2004)
  21. Khan M.A., Islam S., Khan S.A., Zaman G., Muhammad A. and Syed F.S., Application of Homotopy Perturbation Method to Vector Host Epidemic Model with Non-Linear Incidences, Res. J. of Rec. Sc., 2(6), 90-95 (2013)
  22. Mac Donald I.,Science and Technology in the 21st Century: Phytomedicine in Focus, Res. J. of Rec. Sc., (2), 1-7 (2012), 1-4 (2014)
  23. Schmuck G., Klaus A.M., Krötlinger F. and Langewische F.W., Developmental and reproductive toxicity studies on artemisone, Res. B. Dev.Reprod Toxicol,86(2), 131-43 (2009)
  24. Younis Y., J. Med. Chem., 55 (7), 3479–348 (2012)
  25. Lalithambika B., Vani C. and Arayil N.T., Biological Control of Dengue Vector using Pseudomonas fluorescens, Res. J. Recent. Sci,. 3(ISC-2013), 344-351 (2014)
  26. Ahmed R.R., Ahmad N., Nasir F. and Khoso I., Patients’ Satisfaction and Quality Health Services: An Investigation from Private Hospitals of Karachi, Pakistan, Res. J.Recent. Sci., 3(7), 34-38, (2014) , No Hospitals of Karachi, Pakistan, Res. J. Recent. Sci., 3(7), 34-38, (2014)