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Study of Magnesium, Chloride, Lipidperoxidation, Lipidhydroperoxides, among Typeii Diabetic Patients with Elevated Fasting Sugar Level

Author Affiliations

  • 1Dept of Biochemistry IRT Perundurai Medical College, Erode, Tamil Nadu, INDIA
  • 2 Bharathiar University, Coimbatore, Tamil Nadu, India
  • 3Dibetologist Best Diabetic Lab, Gopichettipaayam, Tamil Nadu, INDIA
  • 4IRT Perundurai Medical College, Erode, Tamil Nadu, India
  • 5Dept of Surgery, IRT Perundurai Medical College, Erode, Tamil Nadu, INDIA
  • 6Dept of Physiology, IRT Perundurai Medical College, Erode, Tamil Nadu, INDIA
  • 7IRT Perundurai Medical College, Erode, Tamil Nadu, INDIA
  • 8RVS dental college sulur Coimbatore, Tamilnadu, INDIA
  • 9Dept of Biotechnology, Bharath university Selaiyur, Chennai now adviser Biotechnogy, Chennai, Tamil Nadu, INDIA
  • 10Department of community medicine, All India institute of Medical sciences (AIIMS) New Delhi, INDIA

Res. J. Recent Sci., Volume 3, Issue (ISC-2013), Pages 231-237, (2014)

Abstract

We have compared the level of magnesium, chloride, lipid peroxidation, lipid hydroperoxides among typeII diabetic patients with two groups with low (FD1)154±6.0mg/dL fasting plasma glucose and high (FD2)273 ±10mg/dL fasting plasma glucose. One hundred known type II diabetic patients and one hundred known healhy subjects were compared. The lipid profile study was carried out using standard biochemical methods. We have found magnesium 0.80±0.20mg/dL,chloride52±4mmol/ L was significantly decreased but also there is a concomitant increase in lipid peroxidation 7.4±0.3µ moles/L and lipid hydroperoxide5±1.4µ moles/L among FD2 subject with increase in glucose. The total cholesterol, LDL cholesterol, triglycerides were found to be higher among NIDDM subjects

References

  1. Sarahwild, MB BCHIR, PHD.,Gojka Roglic, MD., Anders Green MD, PHD, DR, MEDSCI., Richardsicree, MBBS, MPH., Hillary King, MD, DSC., Global prevalence of Diabetes, Estimates for the year 2000 and projecting for 2030’ Diabetes care, 27(5), 1047-1053,(2004)
  2. Mohan V., Mathur P., Deepa R., Deepa M., Shukla D.K., Menojn G.R., Anand K., Desai N.G., Joshi P., Mahanta J., Thankappan K.R. and Shah B., Urban rural differences inprevalence of self reported diabetes inIndia—the WHO—ICMR Indian NCD risk factor surveillance, Diabetes Res Clin Pract, 80(1), 159-168 (2008)
  3. Sangeeta C. Sindhu, Obesity Assessment Based on BMI in the young Adults of Haryana-A state of India, Research journal of Recent sciences,2(ISC-2012), 304-307, (2013)
  4. World health Organization Diabetes Mellitus, Report of a WHO study Group, World health Organization technical Report series 727, World Health Organization Geneva (1985)
  5. Trinder P., Determination of blood glucose using an oxidase-peroxidase system with a non carcinogenic chromogen, J.clin pathol, 22(2), 158-161 (1969)
  6. Bergmeyer H.U. etal., D-Glucose determination with Hexokinase and Glucose- 6- phosphate dehydrogenase in Methods of enzymatic analysis 2nd edition., Berg Meyer H.U., Ed., Academic press NewYork,NY,1196- (1974)
  7. Marsh M.H., Fungerhut B. and Miller H. etal., Automated and manual direct method for the determination of blood urea, Clin.chem.,11, 624-627 (1965)
  8. Henry R.J., Clinical chemistry-Principle and Technics (2nd ed) Harper and Row, 548-551 (1974)
  9. Larson K., Creatinine assay by a reaction kinetic Principle, Clin.chim.Acta, 41, 209-17 (1972)
  10. Tarbutton., Gunter, Enzymatic Determination of Total Cholesterol in Serum Clinical Chemistry, 20, 6 (1974)
  11. Assman G., Lipid diagnostic Heute Page 29ff in Greten H etal., Lipoprotein und Herzeinfarkt. Witzstrock -Verlag. Baden-Baden/W. Germany (1979)
  12. Friedewald W.T., Levy R.I. and Fredrickson D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clinical Chemistry, 18(6), 499–502 (1972)
  13. Zhen-Yue Jiang, Alison C.S., Woolard D., Wolff S.P, Hydrogen peroxide production during experimental protein glycation, Febs Lett., 268, 69-71 (1990)
  14. Buege J.A., Aust S.D, Microsomal lipid peroxidation, Methods in Enzymol, 52, 302-310 (1978)
  15. Tietz N.W, Clinical guide to laboratory tests 3rded, Philadelphia, Pa:W.B.Saunders company, 380-382 (1995), 231-237 (2014)
  16. Endres D.B., Rude R.K., Minerals and Bone metabolism In, Burtis C.A., Ashwood E.R, Editors: Teitz textbook of clinical chemistry, 3rd ed, Philadelphia: WB Saunders company, 1395-1457 (1999)
  17. Levinson S.S., Direct determination of serum chloride with a semi automated discrete analyzer, Clin. Chem., 22, 273-274 (1976)
  18. Malaisse W.J., Malaisse-Lagae F., Sener A., Pipeleers D.G., Determination of the selective toxicity of alloxan to the pancreatic cell, Proc.Natl.Acad.Sci.USA, 79, 927936(1982)
  19. Paolisso G., Giugliano D, Oxidative stress and insulin action: is there a relationship?, Diabetologia, 39, 357-363 (1996)
  20. Fox C., Ramsoomar D., Carter C., Magnesium: its proven and potential clinical significance, South Med J, 94, 1195-201 (2001)
  21. Barbagallo M., Dominguez L J., Galioto A., Ferlisi A., Cani C., Malfa L., Pineo A., Busardo A., Paolisso G, Role of Magnesium in insulin action, diabetes and cardiometabolic syndrome X, Mol Aspects Med , 24(1-3)39-52 (2003)
  22. Paolisso G., Barbagallo M., Hypertension,diabetes mellitus and insulin resistance: the role of intracellular magnesium, Am J Hypertens, (10), 346-355 (1997)
  23. Kikuchi Hiroko., Kawakamiyasushi., Kakikanakyoko., Kawaikoich., Murayama Yasuko., lizukayashiaki., Suzukiseiji., SuzukiHiroaki., Sone Hirohito., Toyoshima Hideo., Shimano Hitoshi., Yamada Nobuhiro, Plasma Chloride concentration as a new diagnostic indicator of insulin insufficiency, Diabetes research and clinical practice, 67(2), 137-143 (2005)
  24. Nosratola D Vaziri., B ernardo Rodriguez-Iturbe, Mechanism of Disease: oxidative stress and inflammation in the pathogenesis of hypertension, Nephrology, 2, 582-593 (2006)
  25. Kokko J.P., Jacobson Hr, Renal chloride transport In: Selden DW, Glebisch Geds: The kidney: Physiology and path physiology, New York Raven press, 1097-1117, (1985)
  26. Narins RG., Emmett M, Simple and mixed acid base disorders: a practical approach, Medicine, 50, 161-87, (1980)
  27. Seldin D.W., Rector R.C. Jr, The generation and maintenance of metabolic alkalosis, Kidney int J:, 306-21, (1972)