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Mitochondrial Abnormalities and Pathways of Cancer

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Author Affiliations

  • 1Department of Zoology, Nizam College, Hyderabad, AP, INDIA

Res. J. Recent Sci., Volume 3, Issue (ISC-2013), Pages 1-6, (2014)

Abstract

Mitochondrial DNA (mtDNA) depletes mainly through damaged induced by DNA replication/reading errors and reactive oxygen species (ROS). Endothelial dysfunction (ED) is a result of increased oxidative stress, resulting from electron leakage in the biochemical reactions that occur in mitochondria, and leading to inhibition of nitric oxide (NO) production from endothelial nitric oxide synthase (eNOS). Dysfunction of eNOS leads to development of multiple forms of cancers. An increased reactive oxygen species (ROS) production causes mtDNA damage contributing to ED and accelerated ageing. This review explores an insight into mechanisms of mitochondrial dysfunction in cancer.

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