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Comparative spectral analysis of the effect of ethanolic fruit, leaf and root extract of Solanum macrocarpon on normal human haemoglobin

Author Affiliations

  • 1Medical Unit, Department of Biochemistry, University of Nigeria Nsukka, Enugu State, Nigeria
  • 2Department of Zoology and Environmental Biology, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria
  • 3Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria

Res. J. Recent Sci., Volume 10, Issue (1), Pages 1-7, January,2 (2021)

Abstract

Solanum macrocarpon a plant of the family Solanaceae has been suggested to contain some pharmacological properties that could be useful in the treatment and management of several diseases. However, certain studies have reported the toxic effect of different parts of this plant thereby raising concern about its use in phyto-therapy. Sequel to this, this study was conducted to investigate the effect of different parts of this plant on normal human haemoglobin by spectrophotometry, so as to ascertain the safety of this plant as a potential therapeutic agent. Ten groups consisting of the control and test groups (100 µl, 200 µl and 300 µl of 25 mg/ml fruit, leaf and root extract of Solanum macrocarpon respectively) were used for the study. It was found that the fruit and the root did not cause any toxic effect on haemoglobin whereas the leaf caused significant dose-dependent oxidation of the human haemoglobin especially at higher doses. Therefore, caution should be taken in the use of the leaf extract of Solanum macrocarpon as a therapeutic agent.

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