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Design and Facile Synthesis of 6-(Benzo Thiophen-3-YL)-3-para-Substituted-[1,2,4] Triazolo [3,4-a] Phthalazine Derivatives as Anti-Microbial Agents

Author Affiliations

  • 1Faculty of Engineering Chemistry, SVR Engineering College, Jawaharlal Nehru Technological University-Anantapuramu (JNTU-A), Nandyal, Kurnool (Dist), A.P., India
  • 2Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (AP), India
  • 3Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (AP), India
  • 4Prajna Generics Pvt. Ltd., Hyderabad, Telangana, India
  • 5Dept. of Bio-technology, Sri Krishnadevaraya University College of Engineering & Tech., S.K. University, Anantapuramu–515003 (AP) India

Res.J.chem.sci., Volume 6, Issue (12), Pages 5-17, December,18 (2016)


The article is aimed to synthesize, characterize and screening the biological activity of novel a series of 6-(Benzo Thiophen-3-Yl)-3-Para-Substituted-[1,2,4] Triazolo[3,4-a] Phthalazine Derivatives (8 a-j)with good yields. The newly synthesized compounds were characterized by IR, 1H-NMR, 13C NMR and Mass spectral data. The anti-microbial activity of the novel compounds were screened by disc diffusion method. Compounds 8h, 8g, and 8f demonstrated good antimicrobial activity against all the tested microbial strains. Fused Phialazine 1, 2,4 Triazole linked thiophene with 2,5 di fluoro nucleus has shown good antibacterial and antifungal activities.


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