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A Facile, Rapid, one-pot Synthesis and Biological Evaluation of some Thiadiazole Derivatives

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Author Affiliations

  • 1Chemistry Department, Mahatma Gandhi P. G. College, Gorakhpur-273001, U. P., India
  • 2Chemistry Department, Mahatma Gandhi P. G. College, Gorakhpur-273001, U. P., India
  • 3Chemistry Department, D. D. U. Gorakhpur University Gorakhpur-273009, U.P., India

Res.J.chem.sci., Volume 6, Issue (11), Pages 22-31, November,18 (2016)

Abstract

Some novel thiadiazole derivatives were synthesized through two routes viz.(i) single step reaction of substituted aromatic acid with thiosemicarbazide in presence of POCl3 and (ii) via multistep synthesis by converting substituted aromatic acid to their corresponding esters and then into their hydrazides, which are converted into derivative of their benzoyl thiosemicarbazide followed by cyclization. The structure of the synthesized compounds has been established on the basis of IR, 1H-NMR and 13C-NMR and mass spectrometry. The compounds have been evaluated for antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, Xanthomonas citrii and antifungal against Aspergillus flavus, Aspergillus niger, Alternaria solanii, Fusarium oxysporum, Colletotrichum falcatum and showed moderate to good activities.

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