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Mukaiyama Reagent: Novel One-Pot System for the Synthesis of 1,3-Oxathiolan-5-one

Author Affiliations

  • 1Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati, MS, India
  • 2Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati, MS, India

Res.J.chem.sci., Volume 6, Issue (10), Pages 8-12, October,18 (2016)

Abstract

A new application of mukaiyama reagent for the simple conversion of aldehyde and mercaptoacetic acid into the corresponding 1,3-oxathiolan-5-one is described. The transformation can be achieved in DMF and the method provides rapid and easy access to 1,3-oxathiolan-5-one compounds in good to excellent yields without any chromatographic purification.

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