Antimicrobial studies of novel 2, 5 –Dimercapto-1, 3, 4 –thiadiazole derivatives

International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN. International E-Bulletin: Information/News regarding: Academics and Research

Antimicrobial studies of novel 2, 5 –Dimercapto-1, 3, 4 –thiadiazole derivatives

Author Affiliations

¹Department of Chemistry, Karpagam University, Coimbatore-641 021, Tamilnadu, INDIA
²Department of Chemistry, Karpagam University, Coimbatore-641 021, Tamilnadu, INDIA

Res.J.chem.sci., Volume 5, Issue (1), Pages 12-17, January,18 (2015)

Abstract

A series of novel chalcone derivatives of 2, 5 –Dimercapto-1, 3, 4 –thiadiazole (3a-h) were synthesized by Claisen-Schmidt condensation between terephthaldehydyl -2, 5 –dimercapto (acetichydrazide)-1, 3, 4 –thiadiazole (1) and substituted aromatic ketones (2a-h). All the synthesized compounds (3a-h) were characterized by UV, IR, 1H-NMR, 13C-NMR and mass spectral data. The synthesized compounds were subjected to antibacterial studies against Staphylococcus aureus, Bacillus subtilis (gram-positive), Escherichia coli and Salmonella enteritidis (gram-negative) bacteria and antifungal studies against Candida albicans, Trichophyton rubrum, Trichoderma viride and Aspergillus niger and the Minimum Inhibitory concentration of each compound was determined by liquid broth method. The results indicated that all the synthesized compounds 3a-h showed considerable antibacterial and antifungal activities.

References

Thekke V. Sreevidya, Badiaka Narayana and HemmigeS.Yathirajan, Synthesis and characterization ofsomechalcones and their cyclohexenone derivatives, Cent EurJChem., 8(1), 174-181 (2010)
Google Scholar
Rahman MA., Chalcone : A Valuable Insight into theRecent Advances and Potential PharmacologicalActivities, Chemical Sciences Journal, 29, 1-16 (2011)
Google Scholar
Gheorge Roman, Cyclohexenones through addition ofethylacetoacetate to chalcone derived from 2-acetylthiophene, Acta Chim Slov., 51, 537-544 (2004)
Google Scholar
Yajuvendra S. Dhala, Shiv S. Dulawat and Verma B.L., Solvent free improved syntheses of some substituted 1,3-diarylpropenones and 3, 5-diarl-6-carbethoxycyclohexenones under microwave irradiation and theirantibacterial activity, Indian Journal of Chemistry, 45B,466-469 (2006)
Google Scholar
Ishida S., Matsuda A. and Kawamura,Chemotherapy,8,146(1960), chem.Abstr., , 54, 22844c(1960)
Mehta K.J., Patel V.S. and Parikh A.R., J.indian chem, , Soc., 50, 241 (1978)
Mudaliar V. and Joshi V., Indian J. chem., , 34B, 456(1995)
Hosni G. and Saad S.P., Acta chim.Acad.Sci.Hung., , 86,263(1995); Chem.Abustr., 84, 30959w (1976)
Hishmat O.H., H.I.EI-Diwani and Melek F.R., , Indian J.chem., 35B, 30 (1996)
Liu U.M.,Wilairat P.,Croft S.L.,Tan A.L., Go M.,Bioorg. Med. Chem., , 11, 2729 (2003)
Sivakumar P.M.,Geetha Babu S.K., Mukesh D.,Chem.Pharm.Bull., , 55, 44 (2007)
Rajendra Prasad Y., Lakshmana Rao A. and RambabuR., Synthesis and antimicrobial activity of somechalconederivatives, E-Journal of Chemistry., 5(3), 461-466(2008)
Google Scholar
Sawney S.N., Dhimdsa G.S. and DharmaVir., Synthesisof some 2 heterocyclylphenothiazines as Potential antiinflammatoryagents, J Indian Chem Society, LXV, 643-647 (1988)
Google Scholar
Jignesh P. Raval and Kishor R. Desai, Synthesisandantimicrobial activity of new triazolopyridinylPhenothiazines, ARKIVOC.Xiii, 21-28 (2005)
Google Scholar
Gopalakrishnan M., Thanusu J., Kanagarajan V. andGovindaraju R., Synthesis, antibacterial andantifungalactivities of biolabile (E)-1-(4-morpholinophenyl)-3-arylprop-2-en-1-ones, Med ChemRes., 18, 341-350 (2009)
Google Scholar
Tandel R.C., undefined, undefined
Gohil Jayvirsinth and Patel Nileshk, Synthesisand study of main chalcone polymersexhibitingnematicplaces, Research Journal of RecentSciences., 1, 122-127 (2012), undefined
Hai-Bo Shi, Shi-Jie Zhang, Qiu-Fu Ge, Dian-Wu Guo,Chao-Ming Cai and Wei-Xiao Hu, Synthesis andanticancer evaluation of thiazolyl-chalcones, Bioorganicand Medicinal Chemistry letters., 20, 6555-6559 (2010)
Google Scholar
Mosmann T., Rapid Colorimeteric assay for cellulargrowth and survival: Application to proliferation andcytotoxicity assays, Journal of Immunological methods,65, 55-63 (1983)
Google Scholar
Monks A., Scudiero D., Skehan P., Shoemaker R., PaullK.,Vistica D., Hose C., Langley J., Cronise P., VaigroWolffA., Gray-Goodrich M., Campbell H. and MayoJ. Boyd, Feasibility of high flux anticancer drug Screenusing a diverse panel of cultured human tumor cell lines,Journal of the National Cancer Institute, 83, 757-766(1991)
Google Scholar

[ref1] Thekke V. Sreevidya, Badiaka Narayana and HemmigeS.Yathirajan, Synthesis and characterization ofsomechalcones and their cyclohexenone derivatives, Cent EurJChem., 8(1), 174-181 (2010)
Google Scholar

[ref2] Rahman MA., Chalcone : A Valuable Insight into theRecent Advances and Potential PharmacologicalActivities, Chemical Sciences Journal, 29, 1-16 (2011)
Google Scholar

[ref3] Gheorge Roman, Cyclohexenones through addition ofethylacetoacetate to chalcone derived from 2-acetylthiophene, Acta Chim Slov., 51, 537-544 (2004)
Google Scholar

[ref4] Yajuvendra S. Dhala, Shiv S. Dulawat and Verma B.L., Solvent free improved syntheses of some substituted 1,3-diarylpropenones and 3, 5-diarl-6-carbethoxycyclohexenones under microwave irradiation and theirantibacterial activity, Indian Journal of Chemistry, 45B,466-469 (2006)
Google Scholar

[ref5] Ishida S., Matsuda A. and Kawamura,Chemotherapy,8,146(1960), chem.Abstr., , 54, 22844c(1960)

[ref6] Mehta K.J., Patel V.S. and Parikh A.R., J.indian chem, , Soc., 50, 241 (1978)

[ref7] Mudaliar V. and Joshi V., Indian J. chem., , 34B, 456(1995)

[ref8] Hosni G. and Saad S.P., Acta chim.Acad.Sci.Hung., , 86,263(1995); Chem.Abustr., 84, 30959w (1976)

[ref9] Hishmat O.H., H.I.EI-Diwani and Melek F.R., , Indian J.chem., 35B, 30 (1996)

[ref10] Liu U.M.,Wilairat P.,Croft S.L.,Tan A.L., Go M.,Bioorg. Med. Chem., , 11, 2729 (2003)

[ref11] Sivakumar P.M.,Geetha Babu S.K., Mukesh D.,Chem.Pharm.Bull., , 55, 44 (2007)

[ref12] Rajendra Prasad Y., Lakshmana Rao A. and RambabuR., Synthesis and antimicrobial activity of somechalconederivatives, E-Journal of Chemistry., 5(3), 461-466(2008)
Google Scholar

[ref13] Sawney S.N., Dhimdsa G.S. and DharmaVir., Synthesisof some 2 heterocyclylphenothiazines as Potential antiinflammatoryagents, J Indian Chem Society, LXV, 643-647 (1988)
Google Scholar

[ref14] Jignesh P. Raval and Kishor R. Desai, Synthesisandantimicrobial activity of new triazolopyridinylPhenothiazines, ARKIVOC.Xiii, 21-28 (2005)
Google Scholar

[ref15] Gopalakrishnan M., Thanusu J., Kanagarajan V. andGovindaraju R., Synthesis, antibacterial andantifungalactivities of biolabile (E)-1-(4-morpholinophenyl)-3-arylprop-2-en-1-ones, Med ChemRes., 18, 341-350 (2009)
Google Scholar

[ref16] Tandel R.C., undefined, undefined

[ref17] Gohil Jayvirsinth and Patel Nileshk, Synthesisand study of main chalcone polymersexhibitingnematicplaces, Research Journal of RecentSciences., 1, 122-127 (2012), undefined

[ref18] Hai-Bo Shi, Shi-Jie Zhang, Qiu-Fu Ge, Dian-Wu Guo,Chao-Ming Cai and Wei-Xiao Hu, Synthesis andanticancer evaluation of thiazolyl-chalcones, Bioorganicand Medicinal Chemistry letters., 20, 6555-6559 (2010)
Google Scholar

[ref19] Mosmann T., Rapid Colorimeteric assay for cellulargrowth and survival: Application to proliferation andcytotoxicity assays, Journal of Immunological methods,65, 55-63 (1983)
Google Scholar

[ref20] Monks A., Scudiero D., Skehan P., Shoemaker R., PaullK.,Vistica D., Hose C., Langley J., Cronise P., VaigroWolffA., Gray-Goodrich M., Campbell H. and MayoJ. Boyd, Feasibility of high flux anticancer drug Screenusing a diverse panel of cultured human tumor cell lines,Journal of the National Cancer Institute, 83, 757-766(1991)
Google Scholar