International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Synthesis, Characterization and Antimicrobial activity of some novel schiff Base 3d Transition Metal Complexes Derived from Dihydropyrimidinone and 4- Aminoantipyrine

Author Affiliations

  • 1Sriram Engineering College, Department of chemistry, Perumalpattu, Chennai-602024, Tamil Nadu, INDIA
  • 2PG and Research Department of Chemistry, Presidency College, Chennai–600 005, Tamil Nadu, INDIA

Res.J.chem.sci., Volume 4, Issue (7), Pages 11-17, July,18 (2014)

Abstract

Novel Schiff base and its 3d transition metal complexes of Mn(II), Fe(III) and VO(IV) has been designed and synthesized form 4-aminoantipyrine and Ethyl 4- methyl –oxo-6-phenylhexahyro pyrimidine-5-carboxylate . The ligand and complexes were characterized by physico chemical studies like solubility, melting point, elemental analysis, magnetic susceptibility, conductivity, and spectral studies like IR, UV/VIS spectra. From the data it has been observed that the complexes has the composition of ML2 type and paramagnetic nature, the complexes were coordinated through azomethine nitrogen and pyrazole oxygen of the ligand which was further supported by the appearance of new bands in IR spectra due to v (M-N) v(M-O) and v(M-Cl) .The ligand and its complexes had been screened for their antifungal and antibacterial activities against the fungi(Aspergillusniger ,Candida), and the bacteria (E.coli, Salmonella typhi Bacillus subtilis Staphylococcus aureus,) and showed good antimicrobial activities against the tested bacteria and fungi at 1000,750 and 500 mg/ml. Therefore possible use of the complexes as antibiotic can be suggested.

References

  1. Israa A. Hassan,Transtion Metal Complexes of Bidentte Ligand N-aminoquinolino-2-one and Anthranilic Hydrazide, Research Journal of Chemical Sciences,3(12),50-53,(2013)
  2. Buttrus H. Nabeel and Saeed T. Synthesis and Structural Studies on Some Transition metal complexes of Bis-(benzimidazole-2-thio) ethane, propane and butane ligands, Research Journal of Chemical Sciences,2(6),43-49,(2012)
  3. Z.-L.You and H.-L. Zhu, Syntheses, crystal structures, and antibacterial activities of four schiff base complexes of copper and zinc, Zeitschrift fur Anorganische und Allgemeine Chemie, 630(15), 2754–2760, (2004)
  4. Kabeer A S, Baseer M A, Mote N A, Synthesis and antimicrobial activity of some Schiff bases from Benzothiazoles, Asian. J. Chem., 13(2), 496–500, (2001)
  5. Rajasekar K, Ramachandramoorthy T. and Balasubramaniyan S. Synthesis, Spectral characterization and Crystal structure of [Cd(4-AAP) 2(NO2)2] (4-AAP= 4-Aminoantipyrine), Research Journal of Chemical Sciences, 3(3), 48-51 (2013)
  6. Desai S B, Desai P B , Desai K R , Synthesis of Some Schiff Bases,Thiazolidinones and Azetidinones Derived From 2,6-Diaminobenzo[1,2-D:4,5-D'] Bisthiazole and their Anticancer Activities, Hetrocycl. Commun. 7 (1):83–90, (2001)
  7. Zahid H C, Mohammad S I ,Hummara S I, Claudiu T S, Transition Metal Acetylsalicylates and Their Anti-inflammatory Activity, Journal of Enzyme Inhibition and Medicinal Chemistry, 17(2), 87, (2002)
  8. Sindhukumarn B, Raijuulal G., and Mohanan K, Microwave assisted synthesis, spectroscopic, thermal and biological studies of some Lanthanide (III) chloride complexes with a hetrocyclic Schiff’s bases, Synthesis And Reactivity In Inorganic Metal Organic And Nano- Metal Chemistry39;24,(2009)
  9. Thankamony M. and Mohanan K ,Synthesis, spectral studies, thermal decomposition kinetics, reactivity and antibacterial activity of some lanthanide (II) nitrate complexes of 2-(N-indole-2-one) amino-3-carboxyethyl-4-5-6-7-tetrhy-drobenzo[b]thiophene, Indian journal of chemistry A,46,247-251,(2007)
  10. Raman N, Dhaveethu Raja J, and Sakthivel A, Synthesis spectral characterization of Schiff base transition metal complexes DNA cleavage and antimicrobial activity studies, Journal of Chemical Sciences, 119(4); 303-310,(2007)
  11. Manjula B. and Arul Antony S,Preparation, Characterization, Antimicrobial Activities & DNA Cleavage Studies of Schiff Base Complexes Derived From 4-Amino Antipyrine, Asian Journal of Biochemical and Pharmaceutical Research, 3(1), 168-178 (2013)
  12. Chatterjee N R, Sharma D C, Jadhav G R & Chandak B G, An efficient and Facile Synthesis of Some Ethyl-1-Carbamoyl-4-(2 or 4-Substituted Phenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate Through Ultrasound Accelerated Vilsmeier-Haack Reaction and their Screeening as Antiplatelet and Anticardiac Activity, International Journal of Pharma and Bio Sciences, 1(3) (2010)
  13. Tu S, Xiao-Tong Z, Fang F, Xiao-Jing Z,Song-Lel Z, Tuan-Jie L, Da-Qing S, Xiang-Shan W,Shun-Jun J, One –pot synthesis of 3,4-dihydropyrimidine-2-1(H)-ones using boric acids a catalyst, Tetrahedron Lett ,44 ;6153-6155 (2003)
  14. Wang Y, Yu J, Miao z, Chen R, Bifunctionl primary amine-thioure-TfOH(BPAT-TfOH) as a chiral phase-transfer catalyst; the asymmetric synthesis of dihydropyrimidines, Organic & Bimolecular chemistry,9(8), 3050-3054 (2011)
  15. Electronic supplementary Material (ESI) for RSC Advances, The Royal society of chemistry (2012)
  16. Jayabalakrishnan C, and Natarajan K, Ruthenium (II) carbonyl complexes with tridendtate Schiff bases and their antibacterial activity, Transition.Met.Chem, 27(1);75-79, (2002)
  17. Santha Lakshmi S, Syed Tajueen S, and Kannapan Geetha, Studies on antimicrobial activities of Schiff base complex derived from Dapsone, Journal of Pharmacy Research,4(5); 1531,(2005)
  18. Syed Tajueen S, Santha Lakshmi S, and Kannapan Geetha, Studies on antimicrobial activity of some hydrazones and it copper complexes, Journal of Pharmacy Research, 3(11), 2759, (2010)
  19. Geary W G, The use of conducivity measurements inorganic solve for the characterization of coordination compounds, Coord. Chem Rev, 7(1); 81-122, (1971)
  20. Raman, A Sakthivel, and K.Rajasekaran, Synthesis and Spectral Characterization of Antifungal sensitive Schiff base transition Metal Complexes, Mycobiology, 35(3),150-153, (2007)
  21. -Benzylimino-2, 3-Dimethyl-1-Phenylpyrazal-5-One by Metal Chelation, Research Journal of Chemical Sciences, 1(8), 6-11 (2011)
  22. Mishra A.P, and Pandey, L.R, Synthesis, structure and reactivity of oxovanadium(IV) schiff base, Ind.J .Chem44A,1800-1805,(2005)
  23. Wahid U.Malik,G.D.Tuli,R.D.Madan,Selected Topics in Inorganic Chemistry,First Edition 1976,pp390, Reprint 2004)
  24. Kettle S F A, Physcial inorganic chemistry oxford, UK; spekturm, (1996)
  25. Suman Malik, Suparna Ghosh,Bharati Jain,Archana Singh, and Mamta Bhattacharya, Synthesis, Characterization and Biological Evaluation of some 3d-metalComplexes of Schiff base Derived for Xipamide Drug, International journal of Inorganic Chemistry, 1155,549805 (2013)
  26. Roy S, Nath Mandal T, and Kumar Bariq A, Metal complexes of pyrimidine derived ligands - Syntheses, characterization and X-ray crystal structures of Ni(II), Co(III) and Fe(III) complexes of Schiff base ligands, Polyhedron, 26, 2303 (2007)
  27. Misbah ur Rehman, Muhammad Imran,Muhammad Arif, Synthesis, Characterization and in vitro Antimicrobial studies of Schiff-bases derived from Acetyl acetone and Amino acids and their Oxovanadium (IV) complexes, American Journal of Applied Chemistry, 1(4), 59-66 (2013)
  28. Res. J. Chem. Sci. International Science Congress Association Thimmaiah K N, Lloyd W D and Chandrappa G T, Extractive Spectrophotometric determination of molybdenum (V) in molybdenum steels.Inorg Chim Acta, 81, 106, (1985)
  29. Tweedy B G, Plant extracts with metal ions as potential antimicrobial agents, Phytopathology, 55; 910-914, (1964)
  30. Manjula B., Arul Antony S. and S. Arul Antony,Studies on DNA Cleavage and Antimicrobial screening of Transition Metal complexes of 4-aminoantipyrine Schiff base, Research Journal of Chemical Sciences, 3(12), 22-28, (2013)