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13a-methyl-27-norolean-14-en-3β-ol, a Triterpeneisolated from the stem of Euphorbia Hirta(linn) Possess an Anti-Asthmatic Properties

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Author Affiliations

  • 1Department of Chemistry, Dr. Harisingh Gour University Sagar, MP, INDIA
  • 2Department of Chemistry, Vindhya Institute of Technology and Science, Jabalpur, MP, INDIA

Res.J.chem.sci., Volume 4, Issue (3), Pages 21-26, March,18 (2014)

Abstract

The present study deals with the phytochemical screening of the alcoholic extract of stem of Euphorbia hirta revealed the presence of triterenoid which were subjected to physical, chemical and spectral identification using IR, 1HNMR, 13CNMR and FABMS. On the basis of the spectral data analysis and chemical reactions, the compounds have been established as 13-methyl-27-norolean-14-en-3β-ol namelytaraxerol. The present study has been further designed to evaluate the anti-asthmatic activity of the compound taraxerol. The anti-asthmatic activity was carried out onhistamine induced bronchospasm in guinea pigs which showed that, the alcoholic extract of the stem significantlyinhibited (p < 0.05) the contractile effect of histamine. Thus the alcoholic extracts were found to possess potentantiasthmatic property against guineapig with p values less than 0.05, suggesting their potential for further investigation as anti-asthmatic agent.

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