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Hydroxylamine Hydrochloride as an effective Catalyst for formamide derivative Synthesis and their DPPH scavenging activity

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Author Affiliations

  • 1 Organic Synthesis Laboratory, Department of Chemistry, CBSH, G.B. Pant University of Agriculture and Technology, Pantnagar U.S. Nagar 263 145, INDIA

Res.J.chem.sci., Volume 4, Issue (10), Pages 54-57, October,18 (2014)

Abstract

Hydroxylamine hydrochloride offers simple, efficient, economical and environmentally benign method for amidation at room temperature. The reaction was carried out under neat condition affording most of the products in excellent yield. Plausible mechanism to explain the ability of hydroxylamine hydrochloride to enhance the rate of reaction is described. The method is superior as in this method less amount of formic acid is required and reaction proceeds at room temperature. Synthesized formamides were found to have significant radical scavenging effect on 2,2-diphenyl-1-picryl-hydrazyl radicals.

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