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1, 5 Benzodiazepines: Overview of Properties and Synthetic Aspects

Author Affiliations

  • 1Raj Kumar Goel institute of Technology, Ghaziabad, UP, INDIA
  • 2Banasthali University, Department of Chemistry, Banasthali, Rajasthan, INDIA

Res.J.chem.sci., Volume 3, Issue (7), Pages 90-103, July,18 (2013)


Heterocyclic compounds occur widely in nature and quite a few of these are essential to life processes. The literature on heterocyclic compounds is replete with examples of a large number of synthetic methods of naturally occurring systems which are pharmacologically active. Their practical applications range from clinical use to field as diverse as agriculture, photography, biocide formulations and polymer science. The range of known compounds is virtually limitless, encompassing an impressive spectrum of physical, chemical and biological properties. Extensive applications of these compounds in medicine has led to the chemistry of these materials to expand exponentially in the past few decades, so much so that virtually a limitless series of structurally novel compounds with a broad spectrum of reactivity and stability has been developed . The heterocyclic compounds containing nitrogen has expanded exponentially in the past decades due to their uniquephysical properties , specific chemical reactivity and their remarkable potential biological activities 1,2 .A survey of literature on the nitrogen heterocycles reveal that pyrazole, isoxazole, carbazol, pyrimidine , diazepines and oxazepines tc., are important constituents of a wide variety of natural products with pharmacodynamic application.


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