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Synthesis and Antimicrobial studies of few New Substituted 2-methyl-3-(aryldiazenyl)pyrazolo[5,1-b]quinazolin-9(3H)-ones

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Author Affiliations

  • 1S.S.G.M. College, Loha, Nanded, INDIA
  • 2 Department of Chemistry and Research Center, N.S. B. College Nanded, INDIA

Res.J.chem.sci., Volume 3, Issue (6), Pages 60-68, June,18 (2013)

Abstract

Synthesis of substituted 2-methyl-3-(aryldiazenyl)pyrazolo[5,1-b]quinazolin-9(3H)ones [4a-4t] is carried out by coupling of diazonium salts of aromatic amines [3a-3d] with 2-methylpyrazolo[5,1-b]quinazolin-9(4H)-ones [2a-2e]. The structures of compounds [4a-4t] are confirmed by IR and 1HNMR, 13CNMR and mass spectral studies. Further, they were screened in vitro for antibacterial activity against Escherichia coli and Salmonella typhi. Antifungal activity is evaluated against Aspergillus niger and Penicillium chrysogenum using Paper disc diffusion method. Few compounds have shown potential antibacterial and antifungal activities.

References

  1. Joule J.A. and Smith G.F., Heterocyclic Chemistry, ELBS, London, 2nd ed: 192, 239 (1979)
  2. Katritzky R., Advance in Heterocyclic Chemistry, Academic Press New York, 41, (1963)
  3. Elderfield ed R.C., Heterocyclic Compounds, Wiley, New York, , (1987)
  4. Behr L.C., Fusco R., Jarboe C.H., Heterocyclic Compounds, Pyrazoles, Pyrazolines, Pyrazolidines, Indazoles and Condensed Rings, Wiley, New York, (1967)
  5. Noe F.E., Fowden L. and Biochem J., 77, 543, Chem. Abstr,54, 21345 (1960)
  6. Goodman L.S. and Gilman A., The Pharmacological Basis of Therapeutics, 4th. Ed, (1970)
  7. Albert A., An Introduction to Chemistry of Heterocyclic Compounds, 2nd.ed. Anthlone Press, London, 189-190 (1968)
  8. Beak P., Meisel J.L. and Messer W.R., Tetrahedron Lett, 5315 (1967)
  9. Rovnyak G.C., Millonig R.C. and Schwartz J., Shu V., J. Med. Chem,25 1482–1488 (1982)
  10. Palaska E., Aytemir M., Uzbay I.T. and Erol D., Eur. J. Med. Chem., 36, 539-543 (2001)
  11. Young D.W., Heterocyclic Chemistry, Longman, London (1975)
  12. Acheson R.M., An Introduction to the Chemistry of Heterocyclic Compounds, 3rd ed. John Wiley and Sons, New York.
  13. Wall M.E., Wani M.C., Cook C.E., Palmer K.H., Mephail A.T. and Sim G.A., J. Amer. Chem, Soc, 88, 3888 (1976)
  14. Ferguson LN. Chem. Soc. Rev,14, 289, (1975)
  15. Venkataraman K., Synthetic Dyes, Academic Press New York, 2nd ed, (1971)
  16. Hamer F.M., The Cyanine Dyes and Related Compounds, Interscience, New York (1963)
  17. Bae J.S., Freeman H.S. and El-Shafei A. Dyes and Pigments, 57, 121 (2003)
  18. Sanjay F.T., Dinesh M.P., Manish P.P. and Rajan G.P., Saudi Pharmacutical Journal, 15(1), 48-54 (2007)
  19. Child R.G., Wilkinson R.G. and Tomcu-Fucik A., Chem. Abstr,87 6031 (1977)
  20. Garg H.G., and Prakash C., J.Med. Chem, 15(4), 435-436 (1972)
  21. Jagadish C.S., Thomas C. and Stephen J.K., J. Hetero. Chem., 18, 117-121 (1981)
  22. Cruickshank R.J., Duguid P. and Swain R.R., Medical Microbiology,1, (1998)