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Silicotungstic Acid in Organic Synthesis: Synthesis of 1, 5-Benzodiazepines and β-Amino Carbonyl Compounds

Author Affiliations

  • 1Department of Chemistry, Dr. B. R. Ambedkar National Institute of Technology, Jalandhar - 144011, INDIA

Res.J.chem.sci., Volume 3, Issue (4), Pages 59-64, April,18 (2013)

Abstract

An efficient methodology, employing silicotungstic acid (STA) as catalyst leads to synthesis of 1, 5-benzodiazepines and amino carbonyl compounds, employing condensation reaction of o-phenylenediamine with ketones and one pot three component Mannich reaction at room temperature under solvent free conditions in good to excellent yields. The synthetic protocol offers a novel and improved modification for the synthesis of 1, 5-benzodiazepines and -amino carbonyl compounds in terms of mild reaction conditions and clean reaction profiles, high yields and a simple workup procedure. They are characterised by IR and H NMR spectroscopy.

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