6th International Young Scientist Congress (IYSC-2020) will be Postponed to 8th and 9th May 2021 Due to COVID-19. 10th International Science Congress (ISC-2020).  International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Studies on DNA Cleavage and Antimicrobial screening of Transition Metal complexes of 4-aminoantipyrine Schiff base

Author Affiliations

  • 1PG and Research Department of Chemistry, Presidency College, Chennai–600 005, Tamil Nadu, INDIA

Res.J.chem.sci., Volume 3, Issue (12), Pages 22-28, December,18 (2013)

Abstract

The coordination compounds using Co(II), Ni(II), Cu(II) and Zn(II) ions with Schiff base ligand derived from furfurilydene-4-aminoantipyrine with o-anisidine in a 1:1 molar ratio have been synthesized and characterised by elemental analysis, IR, NMR and electronic spectral studies. On the basis of spectral studies, octahedral geometry is suggested for Co(II), Ni(II), Cu(II) and tetrahedral geometry for Zn(II) complexes. The synthesized ligand and metal(II) complexes have been tested against bacterial speciesPseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and fungal species Aspergillus niger (A. niger), Aspergillus fumigatus (A. fumigatus) and Candida albicans (C. albicans)in order to assess their antimicrobial properties. The results show that the metal complexes were more active than the ligand. The DNA cleavage activity of the ligand and its complexes were assayed using PUCI8 DNA by gel electrophoresis. The result shows that complete cleavage of DNA was observed in Cu(II) and Zn(II) complexes and partial cleavage of DNA was observed in Co(II) and Ni((II) complexes.

References

  1. Bhendkar A.K., Vijay K. and Raut A.W., Acta Ciencia Indica Chem, 30, 29 (2004)
  2. Vaghasiya Y.K., Nair R.S., Baluja M.and Chanda S., J Serb Chem Soc, 69, 991 (2004)
  3. Vashi K. and Naik H.B., Eur J Chem, 1, 272 (2004)
  4. Mtrei R., Yadawe M. and Patil SA., Orient J Chem,12,101 (1996)
  5. Hossain M.E., Allam M.N., Begum J., Akbar M.A., Uddin M.N., Smith F. and Hynes R.C., Inorg Chim Acta,249, 207 (1996)
  6. Kuz’min V.E., Artemenko A.G., Lozytska R.N., Fedtchouk A.S., Lozitsky V.P., Muratov E.N. and Mescheriakov A.K., Environ Res, 16, 219 (2005)
  7. Pal S., Barik A.K., Gupta S., Hazra A., Kar S.K., Peng S.M., Lee G.H., Butcher R.J., Fallah M.S.E. and Ribas J., J. Inorg.Chem., 44, 3880 (2005)
  8. Chohan Z.H., Sumrra S.H., Youssoufi M.H. and Hadda T.B., Euro. J. Med. Chem., , 45, 2739 (2010)
  9. Rosu T., Negoiu M., Pasculescu S., Pahontu E., Poirier D. and Gulea A., Euro. J. Medi. Chem., 45, 774 (2010)
  10. Jones R.D., Summerville D.A. and Basolo F., Chem. Rev 79, 139 (1979)
  11. Olie G.H. and Olive S., The Chemistry of the Catalyzes Hydrogenation of Carbon Monoxide, 152, Springer, Berlin, (1984)
  12. Dugas H. and Penney C., Bioorganic Chemistry”, 435, Springer, New York, (1981)
  13. Margerum J.D. and Mller L.J., Photochromism, 569, Wiley Interscience, New York, (1971)
  14. Sawodny W.J., Riederer M. and Angew. Chem. Int. Edn.Engl. 16, 859 (1977)
  15. Rosu T., Pahontu E., Maxim C. Georgescu R., Stanica N. and Gulea A., Polyhedron 30, 154 (2011)
  16. Mohamed G.G., Omar M.M. and Ibrahim A.A., Euro. J. Med. Chem 44, 4801 (2009)
  17. Raman N., Johnson Raja S. and Sakthivel A., J Coord Chem62, 691(2009)
  18. Raman N., Sobha S. and Thamaraichelvan A., Spectrochim ActaPart A78(2), 888-98 (2010)
  19. Omar M.M., Mohamed G.G. and Ibrahim A.A., Spectrochim Acta Part A, 73, 358 (2009)
  20. Selvakumar P.M., Suresh E. and Subramanian P.S., Polyhedron 26, 749 (2007)
  21. Rajasekar K., Rama chandra moorthy T. and Balasubramoniyan S, Research journal of chemical sciences, 3(3), 48-51 (2013)
  22. Kulendaisamy A., Kavitha T., Angaiarkanni S. and Thillavarasu P., chem. Sci Trans, (2013) in press
  23. Jeena Pearl A. and Abbs Fen Reji T.F., Journal of Chemical and Pharmaceutical Reasearch, 5(1), 115-122 (2013)
  24. Uma Maheswari P., Rajendiran V.,Palaniavar M., Thomas R. and Kullkarni G.U., Inorg. Chem Acta,359, 4601 (2006)
  25. Mudasir K., Wijaya E.T., Wahyuni H., Inoue N. and Yoshioka, Spectrochim Acta Part A, 66, 163 (2007)
  26. Manjula B. and Arul Antony S., Asian journal of Biochemical and Pharmaceutical Research,1(3), 168-178(2013)
  27. Manjula B., Arul Antony S. and Justin Dhanaraj C, Spectroscopy letters, (2013) in press
  28. Vogel A.I., A Tex Book of Quantitative Inorganic Chemistry, Longman Group Limited, 158 (1978)
  29. Haller M. , and GarlandC.W., Experiments in physical chemistry McGraw Hill, Inc., New York and references there in (1962)
  30. Jayabalakrishnan C. and Natarajan K., Transition Met. Chem27, 75 (2002)
  31. Santha Lakshmi S., Syed Tajudeen S. and Kannapan Geetha, Journal of Pharmacy Research, 4(5), 1531-1532(2011)
  32. Syed Tajudeen S., Santha Lakshmi S. and Kannapan Geetha, Journal of pharmacy Research,3(11), 2759-2760(2010)
  33. Sambrook J. Frtsch E.F. and Maniatis T., Molecular Cloning A laboratory manual 2nd Edn (1989)
  34. Anand kumar S Gupta, and Barhate V.D., J Bio Chem Parm Res., , 3(3), 1013 (2012)
  35. Thankamony M. and Mohanan K., Indian J Chem46A, 247.(2007)
  36. Ramesh R., Inorg. Chem Comn, 7, 274 (2004)
  37. Pal S.N. and Pal S., J Chem Soc Dalton Trans, 2102 (2002)
  38. Koushik D., Jagnyeswar R., Mario M., Xin-Yi W., Song G. and Pradyot B., Synthesis crystal structure magnetic property and oxidative DNA cleavage activity of and octanuclear coper(II) complex showing water –perchlorate helical network Journal of Inorganic Biochemistry,101(1),95-103 (2007)
  39. Lindoy L., Moody W.E. and Taylor D., Mass spectral and nuclear magnetic resonance (Proton and carbon-13) study of metal complexes of quadridentate ligands derived from 1,2-diaminoethane and substituted beta diketones, x-ray structure of N,N ethylenebist (5.5-dimethy1-4-oxohexan 2-imininato) nickle (II), Inorg Chem,16, 196 (1977)
  40. Howlader M.B.H. and Islam M.S., Indian J. Chem, 46A,440 (2007)
  41. Raman N., Kulandaisamy A., Thangaraj C., Manisankar P., Viswanathan S. and Vedhi C., Transition Met Chem 29,129 (2004)
  42. Sebastian M., Arun V., Robinson P.P., Leeju P., Varghese D., Varsha G. and Yusuff K.K.M., Template synthesis and spectral characterization of some Schiff base complexes derived from quinoxaline-2- carboxaldehyde and L-histidine. J. Coord. Chem. 64(3), 525-533 (2011)
  43. Mukherji G., Poddar S. N. and Dey K., Nickel(II)Cobalt (II)Copper(II)and Palladium(II)complexes of 1,2-di-(o-salicylidimio phenyl thio) ethane Indian J. Chem.,25A,275(1986)
  44. Raman N., Kulandaisamy A. and Jeyasubramanian K., Chemistry, Sythesis Spectral Redox and Antimirobial Activity of Schiff Transition metal (II) complexes Derived from 4-aminoantipyrine and Benzil, Synth. React Inorg Met-org and Nano-Meta,,32(9), 1583 (2002)
  45. Mohamed G.G. and E1-Wahab Z.H.A., Spectrachimica Acta, 61A, 1059-1068 (2005)
  46. Dharmaraj N., Viswanathamurthi P. and Natrajan K., Trans Met Chem., 26, 105 (2001)
  47. Tweedy B.G., Phytopatology, 55, 910 (1964)
  48. Suraj B., Ade et al, J. Chem. Pharm Res., 4(1), 105-11(2012)
  49. Mohamed G.G., Omar M.M. and Ibrahim A.A., Eur. J. Med Chem., 44, 4801-4812 (2009)
  50. Mishar P., Khare M. and Gautam S.K., Synth. React Inorg Met-Org Chem, 132, 1485-15 (2002)
  51. Anand Prakash Mishra, Herhita purwar Rajendra kumar jain Biointerface research, , 291-299 (2012)
  52. Yang G., Wu F.Z., Wang L., NianFi L. and Tina X., J. Inorg Biochem., 66, 141-144 (1997)