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Various Pharmacological aspects of 2, 5-Disubstituted 1,3,4-Oxadiazole Derivatives: A Review

Author Affiliations

  • 1Dept. of Chemistry and Post Graduate Centre, Abeda Inamdar Sr. College of Arts, Science and Commerce, Camp, Pune – 411001, Affiliated to University of Pune, Pune, INDIA

Res.J.chem.sci., Volume 3, Issue (12), Pages 79-89, December,18 (2013)

Abstract

Heterocyclic compounds possess diverse biological properties that have lead to intense study and research of these compounds. One of these compounds is Oxadiazole which has been found to exhibit various pharmacological activities. 1,3,4-oxadiazole having heterocyclic nucleus is a novel molecule which attract the chemist to search a new therapeutic molecule. 1,3,4-oxadizole exhibited a wide range of biological activities which includes antibacterial, anti-tubercular, anticonvulsant, hypoglycemic, anti-allergic, enzyme inhibitor, vasodialatory, antifungal, cytotoxic, anti-inflammatory, analgesic, hypolipidemic, anticancer, insecticidal, ulcerogenic activities etc. Out of the various derivative 2,5-Disubstituted-1,3,4-oxadiazole is a widely exploited for various application. A large number of drugs used clinically have oxadiazole ring as a structural building block. The capacity of 1,3,4-oxadiazole nucleus to undergo variety of chemical reactions including electrophilic substitution, nucleophilic substitution, thermal and photochemical which make it medicinal backbone on which a number of potential molecules can be constructed. This review has basic information about 2,5-disubstituted-1,3,4-oxadiazole derivatives published in various journals for further development in the field.

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