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Synthesis, Characterization of some Antidiabetic Copper Complexes with Ethylenediamine

Author Affiliations

  • 1Department of Physical Sciences, Faculty of Science and Environment, Mahatama Gandhi Chitrakoot Gramodaya Vishvavidyalaya, Chitrakoot, Satna, MP, INDIA
  • 2Department of Biotechnology, Mahatama Gandhi Chitrakoot Gramodaya Vishvavidyalaya, Chitrakoot, Satna, MP, INDIA
  • 3Mahatama Gandhi Chitrakoot Gramodaya Vishvavidyalaya, Chitrakoot, Satna, MP, INDIA

Res.J.chem.sci., Volume 3, Issue (12), Pages 54-59, December,18 (2013)

Abstract

Biological trace metals such as iron, zinc, copper, and manganese are essential for human health. Development of inorganic pharmaceutical agents is very interesting creation in field of medicinal inorganic chemistry and these agents are being used to treat various chronic diseases with the help of essential elements and other biological trace metals. Metallotherapy is an expanding of interest in the research field of treatment of diabetes mellitus. Especially, orally active anti-diabetic and anti-metabolic syndrome copper complexes have been developed and progressed since last decades, where several highly potent anti-diabetic copper complexes with different coordination structures have quite recently been disclosed, using experimental diabetic animals and enzyme inhibitarory action (α-glucosidase inhibition) also . In the present study we have synthesized, characterized and evaluate % of α- glucosidase of Cu (II) metal complexes and concluded that [Cu (en)3] 2NO3 (complex ) shows lowest IC50 value 0.475 mg/ml while [Cu (en)3] 2Cl (Complex ) shows moderate activity.

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