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Studies on Antivenom Activities of Ficus Iteophyla MIQ and Borassus Aethiopum Plant Extracts against Naja Mossandica Snake Venom

Author Affiliations

  • 1Biochemistry/Chemistry section, Department of Applied Science, Kaduna Polytechnic, Kaduna, NIGERIA
  • 2Biology/Microbiology Department of Applied Science, Kaduna Polytechnic, Kaduna, NIGERIA

Res.J.chem.sci., Volume 2, Issue (9), Pages 1-4, September,18 (2012)

Abstract

The antivenom properties of methanolic extract of Ficus iteophylla miq and Borassus aethiopum plants were investigated against the venom of Naja mossandica snake. Both plant extracts effectively reduced the Naja mossandica venom induced hemolytic activity. The result reveals that hemolysis due to venom was 81.5% without extract but the heomolytic activity was drastically reduced by Ficus iteophylla miq and Borassus aethiopum plant extracts to 41.9% and 61.7% respectively. Pharmacological activities like coagulant, packed cell volume (PCV) and phospholipase A2 were significantly neutralized by both plants extracts. The activity of phospholipase A decreases from 600µmol/min to 267mol/min and 400mol/min by the Ficus iteophylla miq and Borassus aethiopum plant extracts respectively. The investigations revealed that Ficus iteophylla miq and Borassus aethiopum plant extracts posses potent snake venom neutralizing activity. This finding will provide an alternative ways to inhibit venom toxins in snakebite victims and may provide supplemental treatments to serum therapy.

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