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Microwave Assisted Synthesis, Characterization and Antibacterial Activity of Some Arsenic (III) Derivatives of O-Alkyl or O-Aryl Trithiophosphates

Author Affiliations

  • 1Synthetic and Surface Science Laboratory, Dept. of Chemistry, Govt. College, Ajmer (Raj.) 305001, INDIA

Res.J.chem.sci., Volume 2, Issue (5), Pages 57-65, May,18 (2012)

Abstract

Arsenic (III) O-alkyl or O-aryl trithiophosphate of the type ClAs[S2(S)P(OR)] and ROP(S)[SAsS2P(S)OR)]2 (R=Me, Et, Pri, Bui, Ph, CH2Ph) have been synthesized by solvent free microwave assisted procedure from the reaction of arsenic trichloride with potassium salts of O-alky1 or O-aryl trithiophosphate in 1:1 and 2:3 motar ratio respectively. These derivatives have been characterized by elemental analysis, molecular weight determinations and spectroscopic (IR, 1H and 31P NMR) studies. On the basis of them distorted tetrahedral geometry has been proposed for these derivatives. The newly synthesized derivatives show good activity against gram positive and gram negative bacteria and a comparative study of antibacterial effect has also been made with standard drugs.

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