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Synthesis, spectral characterization and biological activity of some novel quinoline substituted Thiazolo [4,5-e] azepines derivatives

Author Affiliations

  • 1Department of Chemistry, Banasthali University, Banasthali-304022, Rajasthan, India
  • 2Department of Chemistry, Banasthali University, Banasthali-304022, Rajasthan, India

Res.J.chem.sci., Volume 10, Issue (2), Pages 21-31, June,18 (2020)

Abstract

A novel series of Quinoline substituted thiazolo fused azepines (3a1-3c3) were synthesized via condensation of N-(5-arylidene- substituted-2-benzylthiazolidin-4-oxo-1,3- thiazolidine-3-yl)-(8-quinolin-yl oxy)-acetamide series (2a-2c) with O-phenyldiamine, O-aminophenol, O-aminothiophenol respectively in the presence of glacial acetic acid and methanol. Compound (2a-2c) were synthesized by condensation of key starting compound N-(4-keto-2-arylthiazolidin-3-yl)-2-(benzazine-8yloxy)ethanamide (1a) with various types of aromatic aldehydes. All these novel compounds were characterized by spectroscopic interpretation methods (i.e. MASS, IR, 1H NMR) and elemental analysis. For all these compounds we have used the micro dilution format to check the amount of antimicrobial agents that is needed to inhibit growth of specific microorganisms.

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