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Synthesis, Spectral and Pharmacological Study of Cu(II), Ni(II) and Co(II) Coordination Complexes

Author Affiliations

  • 1Dept. of Applied Sc. and Humanities, Haryana Engineering College, Jagadhri – 135003, Haryana, INDIA

Res.J.chem.sci., Volume 1, Issue (5), Pages 1-5, August,18 (2011)

Abstract

Complexes of Cu(II), Ni(II) and Co(II) with 2,5–Dihydroxy butyrophenone thiosemicarbazone(L) / 2,5–Dihydroxy benzophenone thiosemicarbazone(L) as primary ligand and 2,2’-bipyridyl(L) as a secondary ligand have been synthesized. Complexes were characterized by analytical data, molar conductance, magnetic measurement, electronic spectra, IR spectra and thermogravimetric analysis. The stereochemistry of the coordination complexes has been confirmed on the basis of electronic, spectral and magnetic moment studies. Racah’s interelectronic parameter(B), Cubic Ligand field splitting parameter (10 Dq) and Nephelauxetic ratio(), g, , h have also been calculated and it has been found that the values are in accordance with the stereochemical structure of the coordination complexes. Elemental analysis and spectral studies suggest the octahedral stereochemistry for all the complexes. Ligands and their complexes with Cu(II), Ni(II) and Co(II) were also screened for their inhibitory effects against four organisms viz; S.aureus, B.megaterium, B.cereus and E.coli by cupplate method. The results of the evaluation of antibacterial activity show that all the synthesized complexes exhibit considerable activities towards all the four pathogenic bacteria. The activity of the mixed complexes has been found to be greater than those of the metal salts and ligands. Moreover, it has also been noticed that the thiosemicarbazones show low activity towards E. coli.

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