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Further Biologically Active Derivatives of 1, 3-Diketones

Author Affiliations

  • 1Department of Chemistry, Gulu University, P.O. Box 166, Gulu, UGANDA
  • 2 Department of Chemistry, Makerere University, P.O. Box 7062, Kampala, UGANDA

Res.J.chem.sci., Volume 1, Issue (5), Pages 80-84, August,18 (2011)


This study presents the synthesis and characterisation of new compounds of antimicrobial activity by the coupling of aromatic aldehydes with 5,5-dimethylcyclohexan-1,3-dione (dimedone). The products were refluxed with N–benzyl-N-phenylhydrazine in acetic acid. With the help of micro- and IR-spectral analysis, the molecular structures of the synthesised products were determined. These were ascertained using H NMR at 60MHz and TMS as internal standard. Biological activity of the derivatives against gram-positive Cocci and Bacilli as well as gram-negative Bacilli was tested and found to vary widely from inactive to highly active, which could prove to be of practical pharmaceutical application.


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