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Antihyperglycaemic Efficacy of Cnidoscolus aconitifolius compared with Glibenclamide in Alloxan-induced Diabetic Wistar Rats

Author Affiliations

  • 1Department of Biomedical Technology, School of Health Technology, Federal University of Technology Owerri, NIGERIA
  • 2 Department of Human Physiology, Faculty of Basic Medical Sciences, University of Port Harcourt, NIGERIA
  • 3 Department of Human Physiology, Faculty of Basic Medical Sciences, Imo State University Owerri, NIGERIA
  • 4 Department of Human Physiology, Faculty of Basic Medical Sciences, Madonna University Elele, NIGERIA

Int. Res. J. Medical Sci., Volume 2, Issue (3), Pages 1-4, March,28 (2014)


Problems associated with the current diabetic pharmacotherapy had further necessitated the need to search for more effective and safer approach to prediabetic and diabetic management. This study investigated the blood glucose lowering efficacy of the chloroform fraction of hydromethanolic leaf extract of Cnidoscolus aconitifolius (CA) compared with Glibenclamide in alloxan-induced diabetic Wistar rats. Statistical analysis of the results using SPSS (v. 15) showed that CA caused a decrease in blood glucose level in a dose-dependent fashion. Comparison of means using paired t-test (p=0.05) showed that 100 - 200mg/Kg of CA showed significant blood glucose lowering potential. 100, 150 and 200mg/Kg of CA lowered the diabetic blood glucose by 41.76. 71.11 and 73.46%, respectively. 150 and 200mg/Kg CA recorded dose- and time-dependent mortality. The percentage difference in blood glucose level caused by 100mg/Kg CA leaf extract was 39.00% compared with 77.48% caused by 0.5mg/Kg glibenclamide. The blood glucose lowering potential of this novel CA extract could be justified by the strong presence of flavonoids in its phytochemical analysis. Effective dose of CA could prevent the rapid hypoglycaemic side effect in glibenclamide usage. However, the results implied that users of CA should be cautious of its possible dose- and time-dependent toxicity.


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