10th International Science Congress (ISC-2020) will be Postponed to 8th and 9th December 2021 Due to COVID-19.  International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Evaluation of Efficacy of Unani Regimen in the Management of post Stroke Spasticity, an open observational Study

Author Affiliations

  • 1Dept. Moalajat (Medicine) National Institute of Unani Medicine, Kottigepalya, Magadi main road, Bangalore, INDIA
  • 2 Dept. Ilaj Bit Tadbeer (Regimenal Therapy), National Institute of Unani Medicine, Bangalore, INDIA
  • 3 Dept. of Moalajat, National Institute of Unani Medicine, Bangalore, INDIA

Int. Res. J. Medical Sci., Volume 1, Issue (11), Pages 29-34, December,28 (2013)

Abstract

Physical rehabilitation and oral antispastic medications are essential in the management of post stroke spasticity, but former alone is inadequate and later causes frequent unwanted side effects. Unani physicians have been treating the disease since ancient times on the principle of Tanqiya (elimination of morbid matter) and Ta’deel (normalization of diseased organ). The limitations of contemporary treatment led to evaluate the efficacy of this therapy on scientific parameters. The study was conducted as open, observational clinical trial enrolling 30 eligible patients. Tanqiya was achieved by using Munzije Balgham and Mus’hile Balgham (in decoction form). Munzije Balgham was given for 13 days, once in the morning, along with 40 grams of Gulqande Asali. Mus’hile Balgham was given mixed with Munzije Balgham on 13th day of the study. Massage of the spastic limbs with Raughane Malkangni was started from 14th day till 28th day of the study for the purpose of Ta’deel. Patients were assessed for spasticity by MAS at baseline, 14th day and 28th day of treatment. Significant difference was observed in antigravity muscles between baseline and 28th day scores (p0.001) using Friedman test with Dunn’s multiple comparison test. Significant difference was observed between baseline and 14th day scores (p0.01) in elbow flexors. No significant adverse change appeared in safety parameters.The test regimen used on the principle of Tanqiya and Ta’deel was found effective in the treatment of spasticity, predominantly in antigravity muscles, probably by enhancing neuroplasticity and by neuroprotective and antispasmodic activities of used drugs.

References

  1. Wissel J, Manack A, Brainin M., Towards an epidemiology of post stroke spasticity, Neurology, 80,13-6 (2013)
  2. Barnes M.P., Johnson G.R., Upper motor neuron Syndrome and Spasticity. 2nd ed. Cambridge, (2008)
  3. Majoosi AIA, Kaamilus Sana'ah. New Delhi: CCRUM, (2010)
  4. Maseehi IIY. Kitabul Mia'h. New Delhi: CCRUM, (2008)
  5. Ibne Rushd M. Kitabul Kulliyat. 1st ed. New Delhi: CCRUM, (1987)
  6. Razi MIZ. Kitabul Hawi. New Delhi: CCRUM, (1997)
  7. Khan MA. Al-Ikseer. New Delhi: Ejaz Publishing House, (2003)
  8. Bohannon RW, Smith MB. Interrater reliability of a Modified Ashworth Scale of muscle spasticity, Phys. Ther.67(2), 206-7 (1987)
  9. Urban PP, Wolf T, Uebele M, Marx Jrj, Vogt T, Stoeter P, et al. Occurence and Clinical Predictors of Spasticity After Ischemic Stroke, Stroke, 41, 2016-20 (2010)
  10. Kirmani NII. Kulliyate Nafeesi, Lahor: Idara Matbua'ate Sulaimani, (1934)
  11. Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J. Hrrison's principles of Internal Medicine. 18th ed. New York: McGraw-Hill Companies, (2012)
  12. Ibne Sina HIA. Al Qanoon Fit Tib. New Delhi: Idara Kitabush Shifa, (2010)
  13. Ibne Betar AIA. Al Jamiul Mufradatul Adviyah wal Aghziyah. 1st ed. New Delhi: CCRUM, (1985)
  14. Rampuri NG. Khazainul Advia, New Delhi: Idara Kitabush Shifa (2005)
  15. Govt.of India MoH&FW. National Formulary of Unani Medicine. New Delhi: CCRUM, (2006)
  16. Bogousslavsky J, Caplon LR, Dewey HM, Diserens K, Donnan GA, Medina MT, et al. Stroke:Selected topics. New York: Demos Medical Publishing, (2007)
  17. Susan BO, Thomas JS. Physical Rehabilitaion. 1st ed. New Delhi: Jaypee Brothers, (2007)
  18. Karimzadeh F, Hosseini M, Mangeng D, Alavi H, Hassanzadeh GR, Bayat M, et al. Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain. Complement Altern Med, 12(76), 1-9 (2010)
  19. Bahr M. Neuroprotection- Models, Mechanisms and Therapies. Gottingen: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, (2004)
  20. Yu XQ, Xye CC, Zhou ZW, Guang C, Du YM, Liang J, et al. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice), Life Sc.,82(1-2), 68-78 (2008)
  21. Tognolini M, Ballabeni V, Bertoni S, Bruni R, Impicciatore M, Barocelli E. Protective effect of Foeniculum vulgareessential oil and anethole in an experimental model of thrombosis, Pharmacol Res, 56(3), 254-60 (2007)
  22. Riaz N, AM, AuR, ZA, PM, Nawaz SA, et al. Lipoxygenase inhibiting and antioxidant oligostilbene and Phytochemistry,65, 1129-35 (2004)
  23. Dhingra D., Parle M., Kulkarni S.K., Memory enhancing activity of Glycyrrhiza glabra in mice, J Ethnopharmaco., 91, 361-5 (2004)
  24. Boskabady 1H, Shafei M.N., Saberi Z. and Amini S., Pharmacological Effects of Rosa Damascena,Iran. J Basic Med Sci,14(4), 295-307 (2011)
  25. Kohli K.R., Nipanikar S.U., Kadbhane K.P., A comprehensive review on Trivrit (Operculina turpethum). Int. J. Pharma Bio Sci.,1(4), 443-52 (2010)
  26. Siddhuraju P, Mohan PS and Becker K., Studies on the antioxidant activity of Indian Laburnum (Cassia fistula L.): a preliminary assessment of crude extracts from stem bark, leaves, flowers and fruit pulp. Food Chem,79(1), 61-7 (2002)
  27. Brashear A. and Elovic E.P., Spasticity-Diagnosis and Management, New York: Demos Medical Publishing, (2011)
  28. Jabeen Q., Aziz N., Afzal Z. and Gilani A.H., Thae spasmogenic and spasmolytic activities of Lavandula stoechas are mediated through muscarinic receptor stimulation and calcium channel blockade, Int J pharm, 3(1), 60-7 (2007)
  29. Lis-Balchin M, Hart S. Studies on the node of action of the essential oil of lavender, Phytother Res,13(6), 540-2 (1999)
  30. Tirapelli CR, Andrade CRd, Adriano OC, Fernando ADS, Sergio RA. and Fernando BdC, et al. Antispasmodic and relaxant effects of the hydroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle, J Ethnopharmacol,110, 23-9 (2007)
  31. Ko FN, Huang TF, Teng CM., Vasodialatory action mechanism of apigenin isolatedfrom Apium graiolence in rat thoracic aorta, Biochim Biophys Acta,115(1) 69-74 (1991)
  32. Khan T, Ahmad M. Spasmolytic and spasmogenic activities of crude extract and subsequent fractions of Paeonia emodi. Pharmazie,62(6), 476-7 (2007)
  33. Gilani AH, Bashir S, Khan A. Pharmacological basis for the use of Borago officinalis in gastrointestinal, respiratory and cardiovascular disorders, J Ethnopharmacol, 114, 393-9 (2007)
  34. Borrelli F, Borbone N, Capasso R, Montesano D, Marino SD, Aviello G, et al. Potent relaxant effect of a Celastrus paniculatus extract in the rat and human ileum, J Ethnopharmacol,122, 234-8 (2009)
  35. Sinha AG. Principles and Practice of Therapeutic Massage. Delhi: Jaypee Brothers, (2006)
  36. Getber DA, Jeffery DR. Clinical Evaluation and Management of Spasticity. New Jersey: Humana Press Inc, (2002)