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Impact of Prolonged Exposure to Oil and Gas Flares on Human Renal Functions

Author Affiliations

  • 1 Department of Human Physiology, College of Medicine and Health Sciences, Imo State University, Owerri, NIGERIA
  • 2 Department of Human Physiology, College Health Sciences, University of Port Harcourt, Choba, NIGERIA
  • 3 Department of Biomedical Technology, School of Health Technology, Federal University of Technology, Owerri, NIGERIA

Int. Res. J. Medical Sci., Volume 1, Issue (11), Pages 9-16, December,28 (2013)

Abstract

This study evaluated the effects of prolonged exposure to oil and gas flares on the renal functions of some residents of the Niger Delta region of Nigeria in the vicinity of the oil and gas flares continually in the order of ten (10) years and above compared to the control subjects drawn from non oil and gas production environments. The subjects were matched for age, sex, educational status and socioeconomic status. Of the 3150 adult volunteers screened, 790 (475 exposed groups and 315 control groups) met the inclusion criteria and participated in the study. Blood samples were collected from all subjects and analyzed for serum concentrations of urea, creatinine, potassium, uric acid and inorganic phosphate. The results showed that the exposed to environmental pollutants of oil and gas origins had statistically significantly increased serum concentrations of urea, creatinine, potassium, uric acid and inorganic phosphate compared with control (p0.05). Our result suggests therefore that individuals exposed to chronic – low level of oil and gas flared associated-environments had raised levels of renal dysfunction biomarkers and thus are more predisposed to developing kidney diseases.

References

  1. World Bank, Defining and Environmental Strategy for the Niger Delta. West Central Africa Department, World Bank, Washington DC, P 150 (1995)
  2. Ukpaka C.P. Characteristics of produced water from an oil terminal in Niger Delta area of Nigeria, Journal of Research in Environmental Science and Toxicology, 1(5), 115-130 (2012)
  3. Ana G.C., Air Pollution in the Niger Delta Area: Scope, Challenges and Remedies, The Impact of Air Pollution on Health, Economy, Environment and Agricultural Sources, Dr. Mohamed Khallaf (Ed.),ISBN: 978-953-307-528-0, (2011) InTech, Available from: http://www.intechopen.com/books/the-impact-of-airpollution-on-health-economy-environment-and-agricultural-sources/air-pollution-in-the-niger-delta-area-scopechallenges-and-remedies. Accessed on January 23, (2013)
  4. Kadaya A.A., Oil exploration and spillage in the Niger Delta of Nigeria, Civil and EnvironmentalResearch, 2(3), (2012)
  5. Anifowose B., Assessing the Impact of Oil & Gas Transport on Nigeria’s Environment, U21 Postgraduate Research Conference Proceedings 1, University of Birmingham UK (2008)
  6. Onuoha F.C., Oil Pipeline Sabotage in Nigeria: Dimensions, Actors and Implications for National Security L/C, African Security Review Institute for Security Studies, 17(3) (2008)
  7. Uyigue E. and Agho M., Coping with Climate Change and Environmental Degradation in the Niger Delta of Southern Nigeria. Community Research and Development Centre Nigeria (CREDC) (2007)
  8. Witter R., Stinson K., Sacket H., Putter S., Kinney G., Teitelbaun D. and Newman L., Potential exposure-related human health effects of oil and gas development: a literature review (2003-2008), (2008) www.ccag.org.au/images/stories/pdfs/literaturereviewwitter et al2008.pdf. accessed 04/01/13 (2013)
  9. McEwen J.D.N. and Johnson M.R., Black carbon particulate matter emission factors for buoyancy driven associated gas flares, Journal of Air Waste Management Association, 62(3), 307-321 (2010)
  10. Kaldany R., Gblobal Gas Reduction Initiative, a paper presented at the IFC Informal Launch Conference of the Global Gas Reduction Initiative, Marakesh, November 8, 2001, Slides 3-7. www.ifc.org/ogc.globalgas.htm. (2001)
  11. Leahey D.M. and Preston K. Theoretical and observational assessments of flare efficiencies, Journal of the Air and Waste Management Association, 51, 1610-1616 (2001)
  12. Kindzierski W.D. Importance of Human environmental exposure to Hazardous air pollutants from Gas flares, Environmental Review, 8, 41-62 (2001)
  13. Strosher M.T., Investigation of Flare Gas Emissions in Alberta; Calgary, Alberta (1996)
  14. Olsgard M.L., Bortolotti G.R., Trask B.R. and Smits J.E.G., Effects of inhalation exposure to a binary mixture of benzene and toluene on vitamin A status and humoral and cell-mediated immunity in wild and captive American kestrels, Journal of Toxicology and Environmental Health, Part A, 71, 1100-1108 (2008)
  15. Robinson S.N., Shah R., Wong V.A. and Farris G.M., Immunotoxicological effects of benzene inhalation in male Spraque-Dawley rats, Toxicology,119, 227-237 (1997)
  16. Strosher M.T., Characterization of emissions from diffusion flare systems. Journal of Air Waste Management Association, 50(10), 1723-1733 (2000)
  17. Johnson M.R. and Kostiuk L.W., Efficiencies of low-momentum jet diffusion flames in crosswinds, Combustion and Flame, 123, 189-200 (2000)
  18. Johnson M.R., Wilson D.J. and Kostiuk L.W., A fuel stripping mechanism for wake-stabilized jet diffusion flames in crossflow, Combustion Science and Technology, 169, 155-174 (2001)
  19. Eyong E.U., Biochemical and toxicological implications following ingestion of shellfish exposed to crude oil polluted water, Ph.D Thesis submitted to the Department of Biochemistry, University of Calabar, Calabar, Nigeria, 329 (2000)
  20. USEPA, United States Environmental Protection Agency (USEPA) (2004): Volatile organic compounds, http://www.epa.gov/volatile organic compounds, Washington DC. (2004)
  21. Nwafor A., Life under assault: no where to hide. University of Port Harcourt Inaugural Lecture Series No 102, (2013)
  22. Agbola T. and Olurin T.A., Landuse and Landcover Change in the Niger Delta Excerpts from a Research Report presented to the Centre for Democracy and Development (2003)
  23. United Nations Development Programme,. Niger Delta Human Development Report. Abuja, Nigeria, 185&186 (2006)
  24. Mba C.H., Environmental Protection and National Development: Towards Optimal Resolution of Conflicting Measures and Strategies. in: Aja Akpuru-Aja and Emeribe Augustine C., Policy and Contending Issues in Nigerian National Development Strategy, John Jacob’s Publishers, Ltd, Enugu, Nigeria (2000)
  25. Aaron K.K., Human Rights Violation and Environmental Degradation in the Niger-Delta, In Elizabeth Porter and Baden Offord(eds), Activating Human Rights, Oxford, Barne, New York (2006)
  26. Oseji O.J., Environmental impact of gas flaring within Umutu-Ebedei gas plant in Delta State, Nigeria, Archives of Applied Science Research, 3(6), 272-279 (2011)
  27. Rosner M.H. and Bolton W.K., Renal function testing, American Journal of Kidney Diseases,47(1), 174-183 (2006)
  28. Idodo-Umeh G. and Ogbeibu A.E., Bioaccumulation of the Heavy Metals in Cassava Tubers and Plantain Fruits Grown in Soils Impacted with Petroleum and Non-Petroleum Activities, Research Journal of Environmental Sciences, 4, 33-41 (2010)
  29. Nwankwo C.N. and Ogagarue D.O., Effects of gas flaring on surface and ground waters in Delta State Nigeria, Journal of Geology and Mining Research, 3(5), 131-136 (2011)
  30. Egwurugwu J.N., Nwafor A., Nwankpa P., Olorufemi O.J., Okwara J.E., Prolonged gas flaring and water quality in Obiakpu, Egbema Imo State Nigeria, International Research Journal Environmental Science,2(4), 1-5 (2013)
  31. Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profile for Benzene (update). US Department of Health and Human Services, Atlanta, Georgia, 200-2004-09793,1-415 (2007)
  32. Lauwerys R. and De Wals P.H., Environmental pollution by cadmium and mortality from renal diseases, Lancet, 1(8216), 383 (1981)
  33. Inskip H., Beral V., McDowall M. Mortality of Shipham residents: 40-year follow-up, Lancet, 896-899 (1982)
  34. Thomas L.D., Hodgson S., Nieuwenhuijsen M. and Jarup L., Early kidney damage in a population exposed to cadmium and other heavy metals, Environ Health Perspect,117(2), 181-184 (2009)
  35. Arisawa K., Nakano A., Saito H., Liu X.J., Yokoo M., Soda M., Koba T., Takahashi T. and Kinoshita K., Mortality and cancer incidence among a population previously exposed to environmental cadmium, Int Arch Occup Environ Health,74, 255-262 (2001)
  36. Arisawa K., Uemura H., Hiyoshi M., Dakeshita S., Kitayama A., Saito H. and Soda M., Cause-specific mortality and cancer incidence rates in relation to urinary 2-microglobulin: 23-Year follow-up study in a cadmium-polluted area, Toxicol Lett, 173(3), 168-174 (2007)
  37. Nishijo M., Nakagawa H., Morikawa Y. et al., Mortality in a cadmium polluted area Japan, Biometals, 17(5), 535-538 (2004)
  38. Nishijo M., Morikawa Y., Nakagawa H., Tawara K., Miura K., Kido T., Ikawa A., E., Kobayashi E. and Nogawa K., Causes of death and renal tubular dysfunction in residents exposed to cadmium in the environment, Occup Environ Med.,63, 545-550 (2006)
  39. Chaney A.L. and Marbach E.P., Modified reagents for determination of urea and ammonia, Clin. Chem., 8, 130 (1962)
  40. Tobacco A., Clinical Chemistry, 25(2), 336 (1979)
  41. Terri A.E. and Sesin P.G. Determination of serum potassium by using sodium tetraphenylboron, Am. J. Clin. Path,29, 86- 90 (1958)
  42. Drewes P.A., Determination of inorganic phosphorus in serum or plasma without deproteinization, Clin. Chem. Acta., 39, 81-83 (1972)
  43. Loghman-Adham M., Renal effects of environmental and occupational lead exposure, Environmental Health Perspective, 105, 928-939 (1997)
  44. Orisakwe O.E., Njan A.A., Afonne O.J., Akumka D.D., Orish V.N. and Udemezue O.O. Investigation into the nephrotoxicity of Nigerian Bonny light crude oil in albino rats, International Journal of Environmental Research and Public Health, 1, 106-110 (2004)
  45. Alderman M.H., Cohen H. and Madhavan S., Distribution and determinants of cardiovascular events during 20 years of successful antihypertensive treatment, Journal ofHypertension, 16, 761-9 (1998)
  46. Bickel C., Rupprecht H.J., Blankenberg S., Rippin G., Hatner G., Daunhauer A. et al., Serum uric acid as an independent predictor of mortality in patients with angiographyically proven coronary artery disease, American Journal of Cardiology, 89, 12-7 (2002)
  47. SatarugS., Nisho M., Lasker J.M., Edwards R.J. and Moore M.R.Kidney dysfunction and hypertension: Role for Cadmium, P450 and Heme Oxygenases, Tohoku Journal of Experimental Medicine, 208, 179-202 (2006)
  48. Siu Y.P., Leung K.T., Tong M.K., Kwan T.H. Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. American Journal of Kidney Diseaes;47, 51-59 (2006)
  49. Talaat, K.M, el-Sheikh, A. R. The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease. American Journal of Nephrology, 27, 435-440 (2007)
  50. Feig D.I, Kang D.H, Johnson R.J. (2008): Uric acid and cardiovascular risk. New England Journalof Medicine, vol 359 (17), 1811-1821 (2008)
  51. Resl M., Clodi M., Neuhold S., Kromoser H., Riedl M., Vila G., Prager R., Pacher R., Strunk G., Luger A. and Hulsmann M. Serum uric acid is related to cardiovascular events and correlates with N-terminal pro-B-type natriuretic peptide and albuminuria in patients with diabetes mellitus. Diabetes Medicine, 29(6), 721-5 (2012)
  52. Ito S., Naritomi H., Ogihara T., Shimada K., Shimamoto K., Tanaka H., Yoshike N. Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan. Hypertension Research, 35, 867-873 (2012)
  53. Guyton A.C. and Hall J.E. Textbook of Medical Physiology, 12th Edition, Sanders, An Imprint of Elsevier, Philadelphia, Pennsylvenia (2010)
  54. Lee J.E., Kim Y.G., Choi Y.H., Huh W., Kim D.J. and Oh H.Y. Serum uric acid is associated with microalbuminuria in prehypertension, Hypertension, 47(5), 962-7 (2006)
  55. Iseki K., Oshiro S., Tozawa M., Iseki C., Ikemiya Y. and Takishita S. Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects. Hpertens.Research, 24, 691-697 (2001)
  56. Tomita M., Mizuno S., Yamanaka H., Hosoda Y., Sakuma K., Matuoka Y., Odaka M., Yamaguchi M., Yosida H., Morisawa H., and Murayama T., Does hyperuricemia affect mortality? A prospective cohort study of Japanese male workers, Journal of Epidemiology, 10, 403-409 2000)
  57. Olanrewaju T.O., Aderibigbe A., Chijioke A., Dada S.A. and Rafiu M.O. Predictors of kidney damage in newlydiagnosed hypertensive Nigerians, Tropical Journal of Nephrology, 5(1), 29-34 (2010)
  58. Gobo A.E., Richard G. and Ubong I.U. Health Impact of Gas Flares on Igwuruta/Umuechem Communities in Rivers State, Journal of Applied Science and Environmental Management, 13(3), 27-33 (2009)
  59. Legramante J.M. and Galante A., Sleep and hypertension: a challenge for the autonomic regulation of the cardiovascular system, Circulation, 112, 786-788 (2005)
  60. Gottlieb D. J., Redline S., Nieto F.J., Baldwin C.M., Newman A.B., Resnick H.E. and Punjabi N.M., Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep, 29(8), 1009-14 (2006)
  61. Dettoni J.L., Consolim-Colombo F.M., Drager L.F., Rubira M.C., Cavasin de Souza S.B.P., Irigoyen M.C., Morstarda C., Borile S., Krieger E.M., Moreno H. and Lorenzi-Filho G., Cardiovascular effects of partial sleep deprivation in healthy volunteers, Journal of Applied Physiology, 113(2), 232-6 (2012)
  62. Perry J.C., Bergamaschi C.T., Campos R.R., Andersen M.L., Montano N., Casarini D.E. and Tufik S. Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats, Journal of Renin-Angiotensin-Aldosterone System, DOI: 10.1177/1470320310391504 (2011)
  63. Modesti P.A., Morabito M., Massetti L., Rapi S., Orlandini S., Mancia G., Gensini G.F. and Parati G. Seasonal blood pressure changes: an independent relationship with temperature and daylight hours, Hypertension, 61(4), 908-14 (2013)
  64. Tedla F.M., Brar A., Browne R. and Brown C., Hypertension in chronic disease: Navigating the Evidence, International Journal of Hypertension, Doi:10, 4061 /2011/132405 (2011)
  65. Anavekar N.S., Mc Murray J.J.V., Velazquez E.J.et al., Relation between renal dysfunction and cardiovascular outcomes after myocardial infacrction, New England Journal ofMedicine, 351(13), 1285-1295 (2004)
  66. Go A.S., Chertow G.M., Fan D., McCulloch and Hsu C.Y., Chronic kidney disease and risks of death, cardiovascular events, and hospitalization, New England Journal of Medicine, 351(13), 1296-1305 (2004)
  67. Diamond G.L. Risk assessment of nephrotoxic metals, In: Tarloff J, Lash L, eds. The toxicology of the kidney, London: CRC Press, 1099-1132 (2005)
  68. Goyer R.A., Mechanisms of lead and cadmium nephrotoxicity, Toxicol Lett,46, 153-162 (1989)
  69. Wasser W.G., Feldman N.S. and D'Agati V.D., Chronic renal failure after ingestion of over-the-counter chromium picolinate, Ann Intern Med,126(5), 410 (1997)
  70. Wani S., Weskamp C., Marple J. and Spry L., Acute tubular necrosis associated with chromium picolinatecontaining dietary supplement, Ann Pharmacother,40, 563-566 (2006)
  71. Bareši M., Gornik I., Radonic R., Zlopasa O., Gubarev N. and Gasparovic V., Survival after severe acute chromic acid poisoning complicated with renal and liver failure, Intern Med., 48(9), 711-715 (2009)
  72. Llobet J.M., Domingo J.L, Colomina M.T., Mayayo, E. and Corbella J., Subchronic oral toxicity of zinc in rats, Bull Environ Contam Toxicol.,41, 36-43 (1988)
  73. Prasad G.V. and Rossi N.F., Arsenic intoxication associated with tubulointerstitial nephritis, American Journal of Kidney Diseases, 26, 373-376 (1995)
  74. Colborn T., Kwiatkowski C., Schultz K. and Bachran M. “Natural Gas Operations from a Public Health Perspective,” International Journal of Human and Ecological Risk Assessment,www.endocrinedisruption.com/files/Oct2011HERA10-48forweb3-3-11.pdf. (2010)