Evaluation of anti-helminthic activity of ethanolic extract of withania coagulans dunal (flower buds)
- 1Periyar College of Pharmaceutical Sciences, Tiruchirappalli, Tamilnadu-620 021, India
- 2Periyar College of Pharmaceutical Sciences, Tiruchirappalli, Tamilnadu-620 021, India
- 3Periyar College of Pharmaceutical Sciences, Tiruchirappalli, Tamilnadu-620 021, India
- 4Periyar College of Pharmaceutical Sciences, Tiruchirappalli, Tamilnadu-620 021, India
Res. J. of Pharmaceutical Sci., Volume 8, Issue (2), Pages 14-17, December,30 (2019)
Withania coagulans is a short shrub with central stem. It has milk coagulating property and various parts of this plant were traditionally used as Emetic, Diuretic and Anti diabetic agent. It is also used in chronic liver failure. Berries of this plant contain amino acids, fatty and essential oil and alkaloids and also show anthelmintic activity. Hence the flower Buds of this plant were examined for anti-helminthic activity using earthworms (Pheretima posthuma). Numerous concentrations (25mgml-1, 50mgml-1, 75mgml-1 and 100mgml-1) of ethanolic extract of Withania coagulans (EEWC) were studied. Albendazole (20mgml-1) was used as standard drug for reference whereas normal saline (NS) as control. The time of paralysis and death of worms were determined and recorded. Extract exhibit significant anti-helminthic activity at the concentration of 75 and 100mgml-1. The result shows that ethanolic extract of Withania coagulans possesses vermicidal activity against earthworms (Pheretima posthuma) and determined to be effective as anti-helminthics. Therefore, the anti-helminthic activity of the ethanolic extract of Withania coagulans dunal (Flower Buds) has been reported.
- Finch R.G., Greenwood D., Whitley R.J. and Norrby S.R. (2010)., Antibiotic and chemotherapy e-book., Elsevier Health Sciences, ISBN: 978-0-7020-4064-1
- WHO, Intestinal worms (2019)., What are intestinal worms (soil transmitted helminthiasis)?., available at https://www.who.int/intestinal_worms/disease/en/ accessed on 10th September 2019.
- Castro G.A. (1996)., Helminths: structure, classification, growth, and development., In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 86. Available from: https://www.ncbi.nlm.nih.gov/books/NBK8282/
- Sharma H.L. and Sharma K.K. (2012)., Principles of Pharmacology., 2nd edition, Paras Publications, 797-808. ISBN : 81-8191-176-8
- Satoskar Nirmala Rege and Bhandarkar S.P. (2015)., Pharmacology and Pharmacotherapeutics., 24th edition, Elseiver Health Science, 815-826. ISBN : 978-81-7991-658-2
- Rang H.P., Dale M.M., Ritter J.M., Flower R.J. and Henderson G. (2011)., Hematopoietic system & treatment of anemia., Rang and Dales Pharmacology. 7th International edition, Churchill Livingstone, 668-672. ISBN : 978-04-4306-911-6
- Gupta V. and Keshari B.B. (2013)., Withania coagulans Dunal (paneer doda): A review., International Journal of Ayurvedic and Herbal Medicine, 3(5), 1130-1136.
- Salwaan C., Singh A., Mittal A. and Singh P. (2012)., Investigation of the pharmacognostical, phytochemical and antioxidant studies of plant Withania coagulans dunal., Journal of Pharmacognosy and Phytochemistry, 1(3), 32-39.
- Ahmad R., Fatima A., Srivastava A.N. and Khan M.A. (2017)., Evaluation of apoptotic activity of Withania coagulans methanolic extract against human breast cancer and Vero cell lines., Journal of Ayurveda and integrative medicine, 8(3), 177-183.
- Pramanick D.D. and Srivastava S.K. (2015)., Pharmacognostic evaluation of Withania coagulans Dunal (Solanaceae)-an important ethnomedicinal plant., Biosci Disc, 6(1), 06-13.
- Gupta P.C. (2012)., Withania coagulans Dunal-an overview., International Journal of Pharmaceutical Sciences Review and Research, 12(2), 68-71.
- Abhishek B. and Thakur Anita (2012)., Anthelmintic acitivity of Cynodon dactylon., Journal of Pharmacognosy and Phytochemistry, 1(3), 1-3.
- Grzybek M., Kukula-Koch W., Strachecka A., Jaworska A., Phiri A.M., Paleolog J. and Tomczuk K. (2016)., Evaluation of Anthelmintic Activity and Composition of Pumpkin (Cucurbita pepo L.) Seed Extracts-In Vitro and in Vivo Studies., Int J Mol Sci., 17(9), 1-21.
- Prashanta K.R. Deb, Ranjib Ghosh, Sankari Das and Tejendra Bhakta (2013)., In vitro Anthelmintic Activity of Acorus Calamus Leaves., Asian J Pharm Clin Res., 3(1), 70-83.
- Patil S., Deshmukh P., Sreenivas S., Sankeertana V., Rekha V. and Anjaiah B. (2012)., Evaluation of Anthelmintic activity of Uncaria gambier Roxb. against Pheretima posthuma., International Journal of Drug Development and Research, 4(4), 234-238.
- Kulkarni Chitrarekha Girish, Lohar Bhagwan Namdev, Jadhav Shital Tanaji and Salunkhe Satyajeet Sunil., (2014)., Evaluation of Anthelmintic Activity of Indian Herbs.
- Agrahari A.K., Meher A., Padhan A.R. and Dash S. (2011)., Assessment of anthelmintic activity of Jussiaea hyssopifolia G. Don., Asian J. Plant Sci. Res, 1(4), 87-91.
- Desai H.P., Kapadia M.D. and Kharat A.R. (2012)., Evaluation of Anthelmintic Activity of Plumbago Zeylanica Linn., IJPSR, 3(11), 4281-4284.
- Dey Y.N. and Ghosh A.K. (2010)., Evaluation of anthelmintic activity of the methanolic extract of Amorphophallus paeoniifolius tuber., Int J Pharm Sci Res, 1(11), 117-121.