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The Role of Natural Antioxidants in Oxidative Stress Induced Diabetes Mellitus

Author Affiliations

  • 1Suresh Gyan Vihar University, Jaipur, Rajasthan, INDIA
  • 2 B.M. College of Pharmaceutical Education and Research, Indore, MP, INDIA

Res. J. of Pharmaceutical Sci., Volume 3, Issue (4), Pages 1-6, April,30 (2014)

Abstract

Diabetes mellitus is a group of metabolic disorder disturbing around 1.5% of the entire population that persisting to present a global health trouble. It is characterized by abnormally elevated levels of blood glucose due to complete or relative insufficiency in insulin secretion and /or insulin action together with chronic hyperglycemia as well as disturbances in carbohydrate, fat and protein metabolism. Diabetes mellitus is coupled with an imbalance among generation of oxygen free radicals and endogenous antioxidant defense that leads to the development of oxidative stress which is partially responsible for diabetes as well as its complications. Several studies have recommended that oxidative stress play a major role in reduced secretion of pancreatic cells, systemic inflammation, endothelial damage and impaired glucose consumption in peripheral tissues, where absolute treatment with insulin as well as oral hypoglycemic agents with no side effect has been difficult. On the other hand, use of antioxidants can be an apparent substitute in patients with diabetes mellitus. Antioxidants obtained from nature helps in neutralization of reactive oxygen species and significantly reduce the probability of progression of diabetic complications. A variety of nutritionally important vitamins, supplements and some constituents of natural food sources including cappers, broccoli, tomatoes, berries, grapes, spinach, carrots, nuts, etc. naturally reduce the injury caused by oxidative stress in diabetes mellitus. Natural products are better known for their traditional use; moreover pharmacy professionals having a sufficient knowledge of such natural products are in a better position to guide patients on their proper use. This review describes the importance of naturally occurring antioxidant in management of diabetes mellitus and its complications.

References

  1. Patel V., Chitra V., Prasanna P.L. and Krishnaraju V., Hypoglycemic effect of aqueous extract of Parthenium Hysterophorus L. in normal and alloxan induced diabetic rats, Ind. J. of Pharmacol., 40(4), 183-185 (2008)
  2. Alteras I. and Saryt E., Prevalence of pathogenic fungi in diabetic patent, Mycopathologia, 67, 157-159 (1979)
  3. Rabini R.A., Fumelli P., Galassi R. Increased susceptibility to lipid oxidation of low-density lipoproteins and erythrocyte membranes from diabetic patients, Metab Clin Exp, 43, 1470–74 (1994)
  4. Chintan A.P., Nimish L.P., Nayana B., Bhavna M., Mahendra G., Hardik T. Cardiovascular complication of diabetes mellitus, J Appl Pharm Sci,4, 1-6 (2011)
  5. Wild S.H., Roglic G., Green A., Sicree R., King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030, Diabetes Care, 27, 1047-53 (2004)
  6. Klavin D.C., The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus, N Engl J Med, 329, 977-86 (1993)
  7. Bylka W., Matlawaska I. Natural flavonoids as antimicrobial agents, The J. of American Nutraceutical Association, 7(2), 24-31 (2007)
  8. Chikezie P.C., Monago C.C. Glutathione s-transferase activity in rats, African J. of Biochemistry research, 3(5), 210-214 (2004)
  9. Dandu A.M., Inamdar N.M. Evaluation of beneficial effect of antioxidant properties of some plants in diabetic rats, Pak. J. of pharma Sci,22(1), 49-52 (2009)
  10. American Diabetes Association, Diagnosis and classification of diabetes mellitus, Diabetes Care, 10, 33-62 (2010)
  11. Davies K.J., Protein damage and degradation by oxygen radicals: IV, Degradation of denatured protein, J Biol Chem, 262, 9914-20 (1997)
  12. Valko M., Leibfritz D., Moncol J., Cronin M.D., Mazur M., Telser J., Free radicals and antioxidants in normal physiological functions and human disease, Int J Biochem Cell Biol, 39, 44-84 (2007)
  13. Kowluru R.A., Chan P.S. Oxidative stress and diabetic retinopathy, Exp Diabetes Res, , 436- 73 (2009)
  14. Agnieszka P., Dorota R., Iren A., Maciej J., Stefan A. High glucose concentration affects the oxidant-antioxidant balance in cultured mouse podocytes, J Cell Biochem, 112, 1661-72 (2011)
  15. Wolff S.P., Diabetes mellitus and free radicals: free radicals, transition metals and oxidative stress in the etiology of diabetes mellitus and complications, Br Med Bull, 49, 642-645 (1993)
  16. Rane R., Gangollia D., Patil S., Ingawale K. Amla, Ashwagandha and Shatavari Formulations as Herbal Medicines and Nutraceuticals, Res. J. Pharmaceutical Sci., 1(3), 10-15 (2012)
  17. Lee S.C., Chang W.J., Lu K.T., Lo D. Wu M.C. Antioxidant capacity and Hepatoprotective effect on Ethanol-injured Liver cell of Lemon Juice concentrates and its comparison with commercial Japanese Apricot Juice concentrates, Res. J. Pharmaceutical Sci., 2(2), 7-14 (2013)
  18. Ha H., Kim K.H. Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C, Diabetes Res Clin Pract, 45, 147-51 (1999)
  19. Nordberg J., Arnér E.J. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system,Free Radic Biol & Medic, 1(31), 1287-312 (2008)
  20. Nishikawa T., Edelstein D.D., Yamagishi S., Matsumura T., Kaneda Y., et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage, Nature, 404, 787-90 (2004)
  21. Ahsan H., Ali A., Ali R. Oxygen free radicals and systemic autoimmunity, Clin Exp Immunol, 31, 398-404 (2003)
  22. Waris G., Alam K. Attenuated antigenicity of ribonucleoproteins modified by reactive oxygen species, Biochem Molec Biol Int, 45, 33-45 (1998)
  23. Hayek T., Kaplan M., Kerry R., Aviram M. Macrophage NADPH oxidase activation, impaired cholesterol fluxes, and increased cholesterol biosynthesis in diabetic mice: a stimulatory role for D-glucose, J of Atheroscler, 195, 277–86 (2007)
  24. Hamblin M., Smith H.M., Hill M.F. Dietary supplementation with vitamin E ameliorates cardiac failure in type 1 diabetic cardiomyopathy by suppressing myocardial generation of 8-iso- prostaglandin F2 and oxidized glutathione, J Cardio, 13, 884–92 (2007)
  25. Rowe L., DNA damage-induced reactive oxygen species: A genotoxic stress response, PhD Thesis, Emory University, Georgia, USA(2009)
  26. Tilethe S., Chourasiy P.K., Dhakad R.S., Kumar D. Potential of Rutin and Vildagliptin Combination against Alloxan Induced Diabetic Nephropathy in Mice, Res. J. Pharmaceutical Sci., 2(9), 1-7 (2013)
  27. Singh R., Sankar C. Screening of the Ethanolic Extract of Rosa Chinensis Jacq Leaves for Free Radical Scavenging Activity, Res. J. Pharmaceutical Sci., 1(2), 29-31 (2012)