PC-Model Studies of 7 methoxy- 2H-3-Aryl-3,4-dihydro-1,3 benzoxazine-Aryl-3, 4-dihydro-4-methyl 7 methoxy -1, 3 benzoxazine Biological activity
Author Affiliations
- 1 Department of Chemistry, Dr. H. S. Gour Central University, Sagar MP, INDIA
Res. J. of Pharmaceutical Sci., Volume 2, Issue (3), Pages 17-25, May,30 (2013)
Abstract
An optimization of the reaction conditions in solvent free and solution phase microwave assisted synthesis of (7 Methoxy) 2H-3-Aryl-3, 4-dihydro-1,3 benzoxazine derivatives.The reported methods for the synthesis of substituted benzoxazine derivatives. 2-Hydroxy3-methoxy benzaldehyde and 1-(2-Hydroxyphenyl) ethanol on the reaction with different primary aromatic amines gave methoxy 2-(arylimino) methylphenols and 2-[1-arylimino) ethyl] phenols respectively Synthesized Compound (1). on reduction with sodium borohydride gave 2- methoxy (arylamino) methylphenols and 2- [1-(aryl amino) ethyl] phenols, Synthesized Compound (2). Which further cyclised with formaldehyde to form the final synthetic derivatives as methoxy 2H-3-aryl-3, 4-dihydro-1, 3-benzoxazines and 2H-3-aryl-3, 4-dihydro-4 methyl- 1,3-methoxy benzoxazines. PC-model values, antimicrobial and antifungal activity studies.
References
- Shakya S., Verma N. and Gupta A., J. Med. Chem.52,5793 (2009)
- Ashok S., Holla B.S. and Kumari N.S., Eur. J. Med. Chem. 42, 380 (2007)
- Harikrishna S. and Limaye S.N, J. Inst. Chemist India, 78,81(2006)
- Katrizky A.R., Singh S.K, Cai C. and Bobrov S, J. Org. Chem.71, 3364 (2006)
- Hansen B. S., Begtrup M. and Ankersen M., Bioorg. Med. Chem. Lett ., 14, 17 (2004)
- Achatzb S. and Domling A., Bioorg. Med. Chem. Lett, 16,6360 (2006)
- Fadda A., Bondock A., Rabie R. and Etman H.A. Turk. J. Chem. 32, 259 (2008)
- Kazemizadeh R. and Ramazani N., AARKIVOC,22, 360 (2002)
- Ferenczi R., and Dinya Z. Antus, Heterocyclic Comp.,11,491 (2005)
- Maiti B., Chanda K. and Sun C., M. Org. Lett., 11, 4826 (2009)
- Tuccinardi T., Calderone V., Curr. Med.14, 3105 (2007)
- Kadi A. and Al-Deeb O.A., Eur.J.Med.42, 235 (2007)
- Ates-Alagoz Z., Yildiz S. and.Buyukbingol E., Chemotherapy, 53, 110 (2007)
- Dyachenko V., Dyachenko V.D. and Rusanov B.E., Russ. J. Org. Chem., 43, 83 (2007)
- Shakya S., Verma N. and Gupta A., J. Med. Chem.52, 5793 (2009)
- Mistry R.N. and Desai K.R., Eur J Chem,2(6), 30 (2005)
- Indorkar D., Limaye N. and Chourasia O.P., Asian J.of Res.chem., 5(9), 1059 (2012)
- Tawab S., Mustafa A. and Kira M., Nature 186, 165 (1960)
- Tuchilus A., Florescu C. and Mangalagiu M.I., J. Heterocycl. Chem.,44, 1149 (2007)
- Moisan A., Rebek L., J. Jr. Org. Lett., , 3733 (2007)
- Rimaz M., Khalafy J. and Noroozi Pesyan N., Aust. J. Chem.,63, 507 (2010)