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S-Triazines: As Alternative Drugs for the Treatments of Typhoid

Author Affiliations

  • 1H.V.P.M. College of Engineering and Technology, HVPM Campus, Amravati-444605, MS, INDIA

Res. J. of Pharmaceutical Sci., Volume 2, Issue (1), Pages 18-19, January,30 (2013)

Abstract

1-substituted-2-thio-(1H)-4-[(2-imino-4-thiobiureto-5-yl) guanyl]-6-substitutedamino-1,2-dihydro-s-triazines [3a(i) to 3f(iv)] have been obtained by the isomerisation of 2-substitutedamino-4-(2-imino-4-thiobiureto-5-yl-carbamidino)-6-substitutedimino-1,3,5-thiadiazines [2a(i) to 2f(iv)] in presence of ethanolic sodium bicarbonate solution, which have been obtained by basification of their hydrochlorides [1a(i) to 1f(iv)] which are synthesized by the interaction of 1-formamidino-3-thioamido-N-substitutedformamidinothiocarbamides and N-aryl/alkylisocyanodichlorides. The latter were prepared initially by the condensation of N-aryl/alkylisothiocyanate and 1,3-Diformamidinothiocarbamide. The structure of all these compounds was established on the basis of elemental analysis and IR and NMR spectral data. All the synthesized compounds have been screened for their antimicrobial activity against both gram-positive and gram-negative human pathogens.

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