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Microwave Assisted Synthesis, Structural Characterization and Biological Activities of 4-Aminoantipyrine and Thiocyanate Mixed Ligand Complexes

Author Affiliations

  • 1P.G and Research Department of Chemistry, Bishop Heber College, (Autonomous), Tiruchirappalli, INDIA
  • 2 Department of Chemistry, St. Joseph’s College, (Autonomous), Tiruchirappalli, INDIA

Res. J. of Pharmaceutical Sci., Volume 1, Issue (4), Pages 22-27, December,30 (2012)


The mixed ligand complexes of Cu(II), Zn(II) and Hg(II) were prepared using 4-aminoantipyrine (4-AAP) and thiocynate ions with microwave irradiation. The prepared complexes were characterized by elemental analysis, conductance measurement, UV-Visible, FT-IR and NMR spectral analysis. The conductivity measurements reveal that the complexes are nonelectrolyte. The elemental analysis showed the formation of 1:2 (metal: ligand) complexes with coordination number 4.The formulae of the complexes are [Cu(AAP)2(SCN)2], [Zn(AAP)2(SCN)2] and [Hg(AAP)2(SCN)2]. The antimicrobial and antifungal activities of the complexes were tested with various microorganisms by disc diffusion method. The antimicrobial results indicate that the metal complexes are moderately active compared to the ligand, 4-aminoantipyrine.


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