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Preparation and Characterization of Swellable Polymer based Gastro-Retentive Zidovudine Superporous Hydrogel Composite

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Author Affiliations

  • 1Department of pharmaceutics, Vignan Pharmacy College, Vadlamudi, Guntur, INDIA
  • 2
  • 3

Res. J. of Pharmaceutical Sci., Volume 1, Issue (2), Pages 13-19, October,30 (2012)

Abstract

The main objective of this research work was to prepare and characterize zidovudine superporous hydrogel composite (sphc). Zidovudine is an anti retroviral agent well absorbed from stomach belongs to the class of narrow therapeutic window so there is a need to prepare a gastro retentive dosage form. Superporous hydrogel composite is a second generation sph. For this preparation acrylic acid, acrylamide monomers were used which shows high water absorbing affinity, N,N methylene bisacylamide was used as a crosslinking agent, N,N,N1,N1Tetrametylethyelenediamine, ammoniumpersulphate as a polymerization initiator pair. Sodiumbicarbonate was used as a gas blowing agent which aids in formation of pores in the structure of sphcomposite. In sphC Ac-Di-Sol was used as a composite material which enhances the mechanical strength of sphC. To characterize the prepared zidovudine sph composite evaluation tests which include swelling ratio, swellingtime, scanning electron microscopy (SEM) analysis were performed, and dissolution studies were carried out to assess release characteristics.

References

  1. N.H Foda, S.M Ali review on Gastro retentive drug delivery systems as a potential tool for enhancing the efficacy of antibiotics, Int. J. of pharma and bio sci (2), 94-104 (2011)
  2. Vishal Gupta N. and Shiva Kumar H.G., Development of a gastro retentive drug delivery system based on superporous hydrogel ,Tropical journal of pharmaceutical research, 9(3),257-261 (2010)
  3. Nr. Baug Arvind, Mehsana superporous hydrogel composite-based bio adhesive drug delivery system, Asian. J of pharm. sci, 5(6), 239-250 (2010)
  4. Kumar Ashok, Pandey Manish synthesis of fast swelling super porous hydrogels, Int. J. of drug delivery,2, 135-140 (2010)
  5. Kumar Amit, Maji Ruma and Bi swarup Das, AsianJ J. of ph.ceutical and clinicalresearch, 3(1), 2-10 (2010)
  6. Hossein Omidian, Kinam Park and Jose G. Rocca, Journal of pharmacy and pharmacology, 59(1), 317–327 (2007)
  7. Kumar Ashok, A review on fast swelling super porous hydrogels, Int. J of drug delivery ref, 2(1), 135-140(2012)
  8. Eytan A Klausner, Eran Lavy, Michael Friedman and Amnon Hoffman, Journal of Controlled Release, 90(1), 143–162 (2003)
  9. Ved Parkash, Jogpal Vikas, Maan Saurabh, Sharma Vidushi, Deepika and Yadav Shiv Kumar, Int. J of pharmacy and life sci, 2(5), 773-781(2011)
  10. Dahiya Amarjeet, Rohilla Ankur, Rohilla Seema and Khan M U, Int. research J . of pharmacy, 2(5), 72-78(2011)
  11. Nayak Kunal. P., Upadhyay Pratik, Jayant Deshpande Arohi RValera and Nirav P Chauhan, Journal of pharmaceuticalresearch and opinion, (1), 1-8 (2012)
  12. Makwana Ami, Sameja Krunal, Parekh Hejal and Pandya Yogi, Journal of drug delivery and therapeutics, 2(3), 12-21 (2012)
  13. Pal Pallavi, Sharma Vijay and Singh Lalit, Journal of drug delivery and therapeutics,2(3), 12-21 (2012)
  14. Bagadiya Abhishek, Kapadiya Maulik and Mehta Kuldeep, Int. J of Pharmacy and Technology, 3(4), 1556-1571 (2011)
  15. Chen J., Blevins W.E., Park H. and Park K., Journal of control release64(1-3), 39-51(2000)