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Dendritic Architechture for the Delivery of Levofloxacin against Resistant Producing Strains

Author Affiliations

  • 1 Department of Biotechnology, Acharya Nagarjuna University,Guntur, AP, INDIA
  • 2 Department of pharmaceutics, Vignan Pharmacy College, Vadlamudi, Guntur, AP, INDIA

Res. J. of Pharmaceutical Sci., Volume 1, Issue (1), Pages 6-9, September,30 (2012)

Abstract

The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-bacterial drug, Levofloxacin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with Levofloxacin and targeted to the resistant producing strains of Klebsiella pneumoniae and E.coli. The antibacterial activity was carried out by cup and bore method to compare the zone of inhibition with standard drug and control (DMSO). The study showed that the Levofloxacin loaded dendrimer has significant antibacterial activity than the plain drug and control treated, but standard drug was not shown zone of inhibition upon both microorganisms. In this study antibacterial activity of synthesized system are also relatively safer and hold potential to deliver some other drugs also.

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