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Distribution of Thalassemia and Hemoglobinopathy in the koch Rajbanshi ethnic group of Jhapa, Nepal

Author Affiliations

  • 1Mechi Multiple Campus, Bhadrapur, Jhapa, Nepal
  • 2Central Department of Zoology, Tribhuvan University, Kirtipur, Kathmandu, Nepal

Int. Res. J. Biological Sci., Volume 9, Issue (2), Pages 35-38, May,10 (2020)

Abstract

Thalassemia and haemoglobinopathies are the most frequent monogenetic haemolytic disorders worldwide. Beta- thalassemia is an emerging global health burden. The study in the different ethnic groups of Nepal regarding incidence of various types of thalassemia is scarce, despite Nepal being included in the World Thalassemia Belt. The current study was done in the Koch Rajbanshi ethnic group of eastern Nepal to determine different varieties of thalassemia and haemoglobinopathies present in them. Three hundred (300) individuals were randomly selected for screening. The screening was done by complete blood count test and microscopical study of peripheral blood smear. The positive samples were further analysed by haemoglobin electrophoresis. Out of total 300 cases 57 cases (19%) showed abnormal red cell indices. Based on the level of haemoglobin A2 and haemoglobin E levels, 26 cases with HbE heterozygote/trait and 31 cases with HbE homozygote/ disease were diagnosed. Hence it was deciphered that haemoglobin variants are a common genetic problem in the Koch Rajbanshi ethnic group.

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