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Nosocomial Klebsiella infection and its virulence factor associated with drug resistance

Author Affiliations

  • 1Department of Microbiology, Yenepoya Medical College, Mangalore, Karnataka, India
  • 2Department of Microbiology, Yenepoya Medical College, Mangalore, Karnataka, India

Int. Res. J. Biological Sci., Volume 6, Issue (4), Pages 48-54, April,10 (2017)

Abstract

Klebsiella species are gram negative bacilli; non-motile bacteria belong to the Enterobacteriaceae family. They are opportunistic pathogens responsible for diseases like urinary tract infection, pneumonia, septicemia, meningitis and soft tissue infections. Chromosomal mutation in the DNA gyrase and DNA topoisomerase IV leads to the plasmid mediated quinolone resistance (PMQR) in Klebsiella spp. The Klebsiella spp. primarily isolated from different clinical samples by the conventional methods. Isolates are further identified by standard biochemical methods and susceptibility testing of PMQR along with MIC is determined by the CLSI guidelines. Phenotypically type 1 and 3 fimbriae can be determined by the hemagglutination assays. Genotypic methods have been proved to be a great tool for detection of virulence and drug resistance genes associated with the Klebsiella infection. This studyalso focus on the virulence factors and most common drug resistant mechanism for quinolone group of antibiotics used in treatment of Klebsiella infection.

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