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A Spectrum of Bacterial Pathogens and its Antibiotic Susceptibility Pattern Isolated from Neonatal Sepsis in an NICU in a Government Pediatric Hospital

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Author Affiliations

  • 1Kasturba Medical College, Mangalore, Manipal University, Karnataka, INDIA
  • 2Kasturba Medical College, Light house, Hill Road, Mangalore, Manipal University, 575001, Karnataka, INDIA

Int. Res. J. Biological Sci., Volume 4, Issue (5), Pages 50-54, May,10 (2015)

Abstract

Neonatal sepsis being one of the major causes for mortality and morbidity in the NICU. This study will provide a data on the bacterial pathogens causing neonatal sepsis along with their antibiogram. To study the spectrum of significant bacterial isolates causing septicemia in neonates and to determine their antimicrobial sensitivity pattern. A total of 784 blood samples were screened for sepsis in newborns less than 28 days old in this retrospective study. The positive blood cultures were detected by BACTEC blood culture systems and antibiotic susceptibility testing was done by using Kirby-Bauer disk diffusion method. Out of 784 samples, 170 were positive blood cultures. Gram negative and gram positive organisms comprised of 79.94% and 18.17% respectively, out of which Burkholderiacepecia complex (30%), Klebsiellaspp.(15.5%) were the most common pathogens followed by S.aureus (14.7%), Among the gram negative organism’s susceptibility for Imipenem, Meropenem and piperacillin/tazobactum was high. All Gram positive bacterial isolates showed 100% sensitivity to Netillin, vancomycin, teicoplanin, rifampacin. Gram negative species has been predominantly seen in neonatal sepsisand Carbapenems is considered one of the best options for empirical antibiotic therapy in our NICU.

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