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The effects of Pulmonary administration of Fe2O3 Nanoparticles on the Lung Tissue in Wistar Rat

Author Affiliations

  • 1Department of Biology, Payam nor university of Isfahan, Isfahan, IRAN

Int. Res. J. Biological Sci., Volume 3, Issue (7), Pages 1-5, July,10 (2014)


Iron oxide nanoparticles are magnetic nanoparticles have widespread application in MRI and heat therapy of cancer as contrast elements. They also used effectively to drug and gene delivery because of effective penetrating to the cells and tissues. However, these features cause Fe nanoparticles have toxic effects that not studied yet completely. In this study, effects of iron oxidenano particles on lung tissue in adult male wistar rats were studied. We used pulmonary inhalation method for nanoparticle administration and used ether as a helper. Our results showed administrated nanoparticles penetrated to the circulation rapidly and created serious inflammation in lung tissues. This study used two different nanoparticle doses (20 and 40 mg/kg) and two different exposing number (7 and 14 times).Histological studies show ednano particle treatment of rats cause pulmonary emphysema, interstitial hyperemia and inflammation in lung. By increasing the administrated dose lung tissue showed all of mentioned symptoms by increased intensity. Nanoparticle exposing causes presence of neutrophils, lymphocytesandeosinophils in the lung tissue that confirmed there is a serious pathologic condition.


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