6th International Virtual Congress (IVC-2019) And Workshop.  International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

The effects of Pulmonary administration of Fe2O3 Nanoparticles on the Lung Tissue in Wistar Rat

Author Affiliations

  • 1Department of Biology, Payam nor university of Isfahan, Isfahan, IRAN

Int. Res. J. Biological Sci., Volume 3, Issue (7), Pages 1-5, July,10 (2014)

Abstract

Iron oxide nanoparticles are magnetic nanoparticles have widespread application in MRI and heat therapy of cancer as contrast elements. They also used effectively to drug and gene delivery because of effective penetrating to the cells and tissues. However, these features cause Fe nanoparticles have toxic effects that not studied yet completely. In this study, effects of iron oxidenano particles on lung tissue in adult male wistar rats were studied. We used pulmonary inhalation method for nanoparticle administration and used ether as a helper. Our results showed administrated nanoparticles penetrated to the circulation rapidly and created serious inflammation in lung tissues. This study used two different nanoparticle doses (20 and 40 mg/kg) and two different exposing number (7 and 14 times).Histological studies show ednano particle treatment of rats cause pulmonary emphysema, interstitial hyperemia and inflammation in lung. By increasing the administrated dose lung tissue showed all of mentioned symptoms by increased intensity. Nanoparticle exposing causes presence of neutrophils, lymphocytesandeosinophils in the lung tissue that confirmed there is a serious pathologic condition.

References

  1. Jani P., Halberd G. W., Langridge J., Florence A. T., Nanoparticle uptake by the gastrointestinal mucosa: quantitation and particle dependency, J. Pharm. Pharmacol.,42, 821-826 (1990)
  2. Indira T. K., Lakshmi P. K., Magnetic Nanoparticles–A Review, Int J Pharm,, 1035-1042 (2010)
  3. Weinstein J. S., Varallyay C. G., Dosa E., Gahramanov S., Hamilton B., Rooney W. D., Muldoon L. L., Neuwelt E. A., Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review, J. Cereb. Blood Flow Metab.,30, 15-35 (2010)
  4. McAuliffe M. E., Perry M. G., Are nanoparticles potential male reproductive toxicant? A literature review, Nanotoxicol., 204-210 (2007)
  5. YousefiBabadi V., Najafi L., Najafi A., Gholami H., BeigiZarji M. E., Golzadeh J., Amraie E., Shirband A., Evaluation of iron oxide nanoparticles effects on tissue and enzymes of liver in rats, J. Pharma. Biomed. Sci.,23, 1-5 (2012)
  6. Gupta A. k., Gupta M., Synthesis and Surfaceengineeringof iron oxide nanoparticles and their biomedical applications, Biomater, 26, 3995-4021 (2005)
  7. Liang X. J., Chen C., Zhao Y., Jia L., Liang X. J., Chen C., Zhao Y., Jia L., Wang P. C, Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials, Curr Drug Metab,, 1-13 (2008)
  8. Espanani H. R, Fazilati M., Sadeghi L., YousefiBabadi V.,Bakhshiani S. Amraie E., Investigation the Zinc Oxide Nanoparticle’s Effect on Sex Hormones and Cholesterol in Rat, Int. Res. J. Biological Sci,, 1-6 (2013)
  9. Zhu M. T., Feng W.Y., Wang Y., Wang B., Wang M., Ouyang H., Zhao Y. L. Chai Z. H., Particokinetics and Extrapulmonary Translocation of IntratracheallyInstilled Ferric Oxide Nanoparticles in Rats and the Potential HealthRisk Assessment, ToxicoloSci,107, 342–351 (2009)
  10. Buzea C., Ivan I., Pacheco Blandino I. I., Robbie K., Nanomaterials and nanoparticles:Sources and toxicity, Biointerphases, , 17-172 (2007)
  11. Yah C. S., Simate G. S., Iyuke S. E., Nanoparticles toxicity and their routes of exposures, Pak J Pharm Sci.,25, 477-91 (2012)
  12. Driscoll K., Costa D., Hatch G., Henderson R., Intracheal Instillation as an Exposure Technique for Respiratory Tract Toxicity: Uses and Limitation, ToxicoloSci, 55, 24-35 (2000)
  13. Borm P. J., Kreyline W., Toxicological hazards of inhaled nanoparticles potential implications durg delivery, J NanosciNanotechnol.,, 521-531 (2004)
  14. Roursgaard M., Inflammatory effects of nanoparticles in lungs of mice, PhD thesis, faculty of health sciences, university of Copenhagen (2009)
  15. Dhandapani S., Subramanian V. R., Rajagopal S., Namasivayam N., Hypolipidemic Effects of CuminumCyminuml on Alloxan-induced diabetic rats, Pharmacol Res., 46, 251-255 (2002)
  16. Berry c. c., Charles S., Wells S., Dalby M. J., Curtis A.S., The influnence of transferrin stabilized magnetic nanoparticles on human dermal fibroblasts in culture, Int. J. Pharm.,269, 211-225 (2004)
  17. YousefiBabadi V., Amraeai E., Salehh H., Sadeghi L., Najafi L., Fazilati M., Evaluation of Iron Oxide nanoparticles effects on tissue and Enzymes ofThyroid in Rats, Int. Res. J. Biological Sci,, 67-69 (2013)
  18. Mital, G. S., Manoj, T. A., Review of Tio2 nanoparticles, Chinese Science Bulletin, 56, 1639-1657 (2011)
  19. Rezaei-Zarchi S., Rad S., Soezi M., Negahdary M., Amrollahi F., Mazaheri G.R., Borna H., Investigation of The effect of Fe2O3 nanoparticles on the blood cells and liver enzymes inmale rat, Adv Environ Biol, 334-342 (2012)
  20. Park E. J., Cho W. S., Jeong j., Yi J. H., Choi k., kim Y., Park K., Induction ofinflammatory responses in mice treated with Crium oxide Nanoparticles by intratracheal instillation, J Health Sci, 56, 387-396 (2010)
  21. Szalasy B., Ogden J. A., Strawbridge R. R., ZE Pierce R., Hoopes P. J., Iron 0xide nanoparticles and their toxicological effects: in vivo and invitro studies. , 7181-7181 (2009)
  22. YousefiBabadi V., Amraeai E., Salehh H., Sadeghi L., Najafi L., Fazilati M., Evaluation of Iron Oxide nanoparticles effects on tissue and Enzymes of Thyroid in Rats, Int. Res. J. Biological Sci, 67-69 (2013)
  23. Dodd N., Jha A. N.,Titanium dioxide induced cell damage:A Proposed of the carboxyl radical, Mutat Res, 660, 79-82 (2008)
  24. Wang L., Ding W., Zhang, F., Acute Toxicity of Ferric Oxide and Zinc OxideNanoparticles in Rats, J NanosciNanotechnol,10, 8617–8624 (2010)