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The Histological and Biochemical effects of Titanium Dioxide Nanoparticle (TiO2) on the liver in Wistar Rat

Author Affiliations

  • 1Department of Biology, Payamnoor University of Isfahan, Isfahan, IRAN
  • 2Department of Biochemistry, Payamnoor University of Isfahan, Isfahan, IRAN

Int. Res. J. Biological Sci., Volume 3, Issue (6), Pages 1-5, June,10 (2014)


Nanoparticles have wide spread application in all aspects of modern life because of unique features of their as small size and high surface area. Their features especially high surface area cause it is very reactive and toxic. They can damage human and animal cells by increasing oxidative stress mechanism. Nanotitanium dioxide (TiO2) having different capabilities such asrobustoxidation, biocompatibility, photocatalytic properties frequently used in a wide range of sciences, including pharmaceuticals, cosmetics, medicine and engineering. Wide application of this materials resulted wide exposing of human and animals to this, so analysis of its toxicity and distribution in the body is important. This study investigates the effects of TiO2 nanoparticle on the concentration of hepatic hormones such as AST, ALT and ALP. Results showed significant alteration in ALT and ALP concentration, also histological studies showed any important changes in liver tissue that indicate toxic effects of nanoTiO2 on liver health.


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