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The Pathogenic Potentials of Salmonella typhi specific Human and Lapin Cryoglobulins in a Lapin Model

Author Affiliations

  • 1University of Babylon, College of Science, Department of Biology, Hilla P.O.Box, 4 IRAQ

Int. Res. J. Biological Sci., Volume 3, Issue (5), Pages 57-61, May,10 (2014)


A three doses of 5 mg\ml in foure days a part of human (Xenogenic) and rabbit (Allogenic) cryoglobulins were used for intravenous inoculation in two separated groups each of three. These dosage regmine were followed by seven days leave, then, sacrifice. A third group of three rabbits were receiving saline in same protocol. Pneumogenic effects were found as interstitial pneumonia and fibrinoid formation. Nephrogenic influence appeared as glomerular infiltrates of mononuclear cells (glomerulonephritis). While the splenic changes were found as lymphoid cells hyperplasia in the white pulp. Thus, both of the allogenic and xenogenic cryoglobulins induce Pneumogenic, nephrogenic as well as lymphogenic pathogenic potentials in rabbits. Control rabbits were showing normal tissue architecture of the test organs. These pathogenic potentials of cryoglobulins are basically of immune complex hypersensitivity in case of human cryoglobulins and pathologic autoimmune responses in case of rabbit cryoglobulins. Thus, S. typhi specific cryoglobulins pathogenic in a lapin model, a finding is not ever being reported in literatures and reported for the first time.


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