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Association between Plasma Cholesteryl Ester Transfer Protein activity and Lipid profiles in Metabolic Syndrome in an Iranian Population

Author Affiliations

  • 1Research Center for Molecular Medicine, Hamadan University of Medical Science, Hamadan, IRAN
  • 2 Department of Biochemistry and Nutrition, School of Medicine, Hamadan University of Medical Science, Hamadan, IRAN
  • 3v Department of Internal Medicine-Endocrinology, Medical School, Hamadan University of Medical Science, Hamadan, IRAN

Int. Res. J. Biological Sci., Volume 3, Issue (4), Pages 87-90, April,10 (2014)

Abstract

Metabolic syndrome (MS) is a predisposing factor for atherosclerosis, cardiovascular disease (CVD) and type 2 diabetes. Cholesteryl ester transfer protein (CETP) has a major role in the lipoproteins metabolism and subsequently lipid profile. This study was aimed to investigate possible relationship between plasma CETP activity and lipid profile in metabolic syndrome in a population from Iran. In this case-control study a total of 400 participants, 200 healthy individuals and 200 patients with metabolic syndrome were selected from residents of Hamadan city in western regions of Iran. A national Cholesterol Education Program guideline was used to diagnosis of MS. Blood sugar, lipid profile, and BMI were determined in all studied subjects. A fluorometric assay was used to measure the plasma CETP activity. Significant differences in lipid profile and waist circumference were observed between two studied groups (p=0.001). CETP activity was significantly higher (p0.001) in patients compared to normolipidaemic group. Correlation analysis showed an association between CETP activity and total cholesterol, LDL cholesterol, and HDL-C. Our results suggest that individual with MS has increased CETP activity. Augmented CETP activity and its association with reduction in HDL-C and increase in LDL-C indicate the important role of CETP in alteration of lipid profile and probably pathogenesis of MS.

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