6th International Young Scientist Congress (IYSC-2020) will be Postponed to 8th and 9th May 2021 Due to COVID-19. 10th International Science Congress (ISC-2020).  International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

The Effects of Oral Methyl Tert-Butyl Ether (MTBE) on Mouse Sperms

Author Affiliations

  • 1Department Of Biology, College of Science, Boroujerd Branch, Islamic Azad University, Boroujerd, IRAN

Int. Res. J. Biological Sci., Volume 3, Issue (2), Pages 74-75, February,10 (2014)


Methyl Tert_Butyl Ether (MTBE) is an organic oxygenated compound for decreasing Carbon Monoxide emissions during combustion. In this research, the effect of MTBE on the NMRI mice sperm was studied, MTBE was administered to mice at dose levels of 1600 mg/kg/day. After two weeks of treatment, the mice were anesthetize, and their testes and epididymis were removed. Their epididymal ducts were dissected, then the sperms were studied. No Significant changes were observed in the number of sperms, but sperms` viability had been decreased significantly .This experiment indicates that, relatively high dose of MTBE can exert toxicity on cells in the mouse sperms.


  1. Hazardous Substance Data Bank (HSDB), t-Butyl Methyl Ether, Bethesda, Maryland : Nationallibrary of Medicine (NLM), National Toxicology program (NTP) (1997)
  2. Lewis R.J., Methyl tert Butyl Ether (MTBE) . Hawleys condensed chemical dictionary, 12thed. New York, van Nostrand Rein hold co., 760 (1993)
  3. Pozzi R., Pinelli P.F., Bocchini P. and Galleti G.C., Rapid determination of MTBE using dynamic head space, Ion mobility spectrometry,Analytica Chemica Acta., 504(2,23), 313-317 (2004)
  4. Inter agency assessment, Washington, DC, National science and Technology council, 2-56 (1997)
  5. Mackay D. and Wan Y.S., Illustrated hand book of physical chemical properties and environment fate for organic chemical, volatile organic chemicals, Boca Rotan, FL: Lewis publisher, 3 (1993)
  6. Environmental Canada. Canadian environmental protection act priority substances list supporting document, Methyl Tertiary Butyl Ether (MTBE), january. Ottawa, Canada, Canada communication grouppublisher, GoVerment of Canada,28 (1993)
  7. Borden R.C., Black D.C., MCB life, K.V. MTBE and aromatic hydrocarbons in north Carolina storm water runoff. Environmental pollution, 118(1),141(2002)
  8. Jacobs J., MTBE : effects on soil and ground water resources, 24 (2001)
  9. Chun J.S., Methyl Tertiary-Butyl Ether ,Vapor inhalation on cogenicity study in fischer 334 rates, Bushy Run center, Export Pennsylvania, project No. 91Noo 13B (1992)
  10. Ghasemi J., Noroozi M., Mohebi M.A. and et al., A general view to the Methyl tert - Butyl Ether (MTBE), Chemistry Department, Razi university, Kermanshah, Iran, Research Institute of Petroleum Industry (2005)
  11. Rezazadeh M., Intera cytoplasmic injection,Tehran Boshra publisher (2002)
  12. Hafezi M., Effect of oral MTBE on the male mouse reproductive system, World A cademy ofscience, Engineering and Tecnology, 60 (2009)