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Normal values of Thyroid Ultrasound Volume of School Children in non-iodine deficiency area Abomey Calavi in Benin

Author Affiliations

  • 1Laboratoire de Biomembranes et de Signalisation Cellulaire, Département de Physiologie Animale, Faculté e des Sciences et Techniques, Université d’Abomey- Calavi, Cotonou, REPUBLIQUE DU BENIN
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Int. Res. J. Biological Sci., Volume 2, Issue (9), Pages 29-33, September,10 (2013)

Abstract

According to WHO, the school-age children are more vulnerable to disorders caused by iodine deficiency (IDD). The prevalence of goiter in this age is an indicator of the severity of these disorders in a population. Assessing the prevalence in a moderately iodine-deficient area is more reliable by measurement of thyroid ultrasound volume (TUV) than palpation method. This study aims to define the upper limits of normal TUV which can be referenced in school children aged 06 to 12 years of Abomey-Calavi. A coastal city apparently without iodine deficiency and the most populous of Atlantic Department in southern Benin. Inclusion criteria were formulated. Children were selected at random in a cluster of 09 schools. For each of them, urinary iodine was measured, anthropometric parameters (age, sex, height, weight) were recorded and ultrasound explorations were performed to calculate TUV. The normal upper limits are the 97th percentiles of TUV calculated firstly according to age and sex and the other based on sex and body surface area (BSA). Study population includes 134 schoolchildren, 68 girls (50.70%) and 66 males (49.3%). The urinary iodine was between 100 µg / l and 300g / l in 93.3% of children and 300 and 400 µg / l for others. In girls, 97th percentiles of TUV were respectively by age categories (06 to 12) years: 1.99 ml; 2.71 ml; 2.06 ml; 2.54 ml; 4.70 ml; 3.81 ml; 5.22 ml. For boys, respectively: 1.82 ml ; 2.11 ml ; 2.19 ml ; 2.80 ml ; 3.06 ml ; 4.6 ml ; 3.9 ml. TUV were normal in 91.04% of children. According to BSA, 97th percentiles of TUV for girls were: 2.04 ml; 3.86 ml; 2.05 ml; 3.63 ml, 4.7 ml, 5.25 ml, 3.88 ml, 4.38 ml, in boys nc; nc; 1.19 ml; 2.89 ml; 3.52 ml; 3.93 ml; 4.22 ml; 4.83 ml; nc (nc = not considered). The TUV were normal in 88.06% of schoolchildren. Upper limits of normal TUV values obtained wee fairly consistent and could serve as references for the interpretation of survey and monitoring data obtained by ultrasound in school children.

References

  1. WHO; UNICEF; ICCIDD,Assessment of iodine deficiency disorders and monitoring their elimination. A guide for programme managers. GenevaWHO/NHD01, 1, 107 (2001)
  2. WHO; UNICEF; ICCIDD, Indicators for assessing iodine deficiency disorders and their control through salt iodization. Geneva: WHO, (WHO/NUT/94.6.) (1994)
  3. Tapsoba T.L., Ouédraogo T.B., Nacro B., O. Diallo O. and Niampa M.Mensurations échographiques de la thyroïde chez des enfants de zéro à 15 ans de la ville de Ouagadougou, Med. Nucl., 32(11), 573-579 (2008)
  4. Marwaha R.K., Tandon N., Ashraf G.M., Ganguly S.K., Batra A., Aggarwal R., Kalaivani Mani, and Singh S., Ultrasound evaluation of thyroid size: A large nationwide study of schoolchildren in India, Nat. Med. J. India, 21, 69–74 (2008)
  5. Zimmermann M.B., Hess S.Y., Molinari L., De Benoist B., Delange F., Braverman L.E., Fujieda K., Ito Y., Jooste P.L., Moosa K., Pearce E.N., Pretell E.A. and Shishiba Y., New reference values for thyroid volume by ultrasound in iodine sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report, Am. J. Clin. Nutr., 79, 231–7 (2004)
  6. Zimmermann M.B., Saad A., Hess S.Y., Torresani T. and Chaouki N.,Thyroid ultrasound compared with world health organization 1960 and 1994 palpation criteria for determination of goiter prevalence in regions of mild and severe iodine deficiency, Eur. J. Endocrinol., 143, 727–31 (2000)
  7. Tonglet R., Bourdoux P., Dramaix M., Hennart P. and Ermans A., Interobserver variation in the assessment of thyroid enlargement: a pitfall in surveys of the prevalence of endemic goiter, Food Nutr Bull,15, 64–70 (1994)
  8. Xu F., Sullivan K., Houston R., Zhao J., May W. and Maberly G.,Thyroid volumes in US and Bangladeshi schoolchildren: comparison with European schoolchildren,Eur. J. Endocrinol., 140, 498–504 (1999)
  9. Seker S. and Tag I.,Determination of Thyroid Volume and Its Relation with Isthmus Thickness,Eur JGen Med, 7(2), 125-1292010 10.Dunn J.T., Crutchfield H.E., Gutekunst R. and Dunn A.D.,Methods for Measuring Iodine in Urine, International Council for Control of Iodine Deficiency Disorders,(1993)
  10. Dubois D. and Dubois E.F., Clinical colorimetry, Tenth paper, A formula to estimate the approximate surface area if height and weight be known, Archives of International Medicine,17, 863-871 (1916)
  11. Brunn J., Block U., Ruf G., Bos I., Kunze W.P. and Scriba P.C.,Volumetric analysis of thyroid lobes by real-time ultrasound, Deutsche Medizinische Wochenschrift,(106-41), 1338–1340 (1981)
  12. WHO, ICCIDD,Recommended normative values for thyroid volume in children aged 6 15 years, Bull. WHO, 75, 95-97 (1997)
  13. Zimmermann M.B., Molinari L., Spehl M., Weidinger-Toth J., Podoba J., Hess S. and Delange F.,Towards a consensus on reference values of thyroid volume in iodine replete schoolchildren results of workshop on interobserver and interequipment variation in sonographic measurement of thyroid volume, Euro. J. Endo., 144, 213-20 (2001)
  14. Ancelle T.,Statistique épidémiologie, édition, Paris : Maloine,300 (2006)
  15. Schwartz D., Statistique médicale et biologie, édition, Paris : Flammarion, 125 (1985)
  16. Snu Benin, Bilan Commun de Pays. Système des Nations Unies au Bénin (2002)
  17. OMS, Série sur les micronutriments :Indicateurs d’évaluation des troubles dus à la carence en iode et de la lutte contre ces troubles par l’iodation du sel. Genève, WHO/NUTm (94.6), 50 (1994)
  18. Roti E.; Degli Uberti E., Iodine excess and hyperthyroidism, Thyroid., (11), 493–500 (2001)
  19. Aghini-Lombardi F., Antonangeli L., Pinchera A., Leoli F., Rago T. and Bartolomei A., Effect of iodized salt on thyroid volume of children living in an area previously characterized by moderate iodine deficiency, Journal of Clinical Endocrinology and Metabolism, 82, 1136–1139 (1997)
  20. Ivarsson S.A., Persson P.H. and Ericsson U.B., Thyroid gland volume as measured by ultrasonography in healthy children and adolescents in non-iodine deficient area, Acta Paediatrica Scandinavica, (78), 633-634 (1989)
  21. Zimmermann M.B., Hess S.Y., Molinari L., de Benoist B.; Delange F. and Braverman L.E., New reference values for thyroid volume by ultrasound in iodine sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report, Am. J. Clin. Nutr., 79, 231-7 (2004)
  22. 3. Ntambwekibambe T., Acakpo A., Ouedraogo A. and Salami M., Evaluation rapide des troubles dus à la carence en iode : le projet Thyromobil dans six pays d’Afrique de l’Ouest, Nutrition Third World Brussels, 51-62 (2004)